About: Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). (en)
Title	Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients (en)
skos:prefLabel	Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients (en)
skos:notation	RIV/00216224:14740/14:00077330!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NT13514)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jančálek, Radim RADOVÁ, Lenka Slabý, Ondřej Šána, Jiří Šlampa, Pavel Hermanová, Markéta Lakomý, Radek Křen, L. Smrčka, Martin Vyzula, Rostislav Svoboda, Marek Fadrus, Pavel Bešše, Andrej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	42827
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00077330
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier (en)
http://linked.open.../riv/klicoveSlovo	glioblastoma multiforme expression profiling microRNA prognostic classifier risc score
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[52AB43C7F413]
http://linked.open...i/riv/nazevZdroje	Carcinogenesis
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	13 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Hermanová, Markéta Jančálek, Radim Radová, Lenka Slabý, Ondřej Šlampa, Pavel Šána, Jiří Křen, Leoš Lakomý, Radek Smrčka, Martin Svoboda, Marek Vyzula, Rostislav Hajdúch, Marian Fadrus, Pavel Nekvindová, Jana Bešše, Andrej
http://linked.open...ain/vavai/riv/wos	000345836200015
issn	0143-3334
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/carcin/bgu212
http://localhost/t...ganizacniJednotka	14740

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