About: Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice.

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About: Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/ijlh.12149/pdf
Description	Introduction Minimal residual disease (MRD) detection has become increasingly important for the assessment of therapy response in chronic lymphocytic leukemia (CLL). However, current MRD analysis methods, both molecular genetic and flow cytometric, are time-consuming and require experienced laboratory staff. Methods To reduce the demands of flow cytometric MRD detection in CLL, we have introduced a novel flow cytometric 8-color protocol. The MRD analysis results using this protocol were then compared with the commonly employed 4-color protocol and the molecular genetic (real-time quantitative allele-specific oligonucleotide IGH polymerase chain reaction; RQ-ASO IGH PCR) approach. Results Forty-two CLL patient samples were repeatedly analyzed after allogeneic stem cell transplantation (n=20) or after fludarabine-based therapy (n=22), and 100% concordance was found using both flow cytometric protocols. Furthermore, there was a strong correlation (r=0. Introduction Minimal residual disease (MRD) detection has become increasingly important for the assessment of therapy response in chronic lymphocytic leukemia (CLL). However, current MRD analysis methods, both molecular genetic and flow cytometric, are time-consuming and require experienced laboratory staff. Methods To reduce the demands of flow cytometric MRD detection in CLL, we have introduced a novel flow cytometric 8-color protocol. The MRD analysis results using this protocol were then compared with the commonly employed 4-color protocol and the molecular genetic (real-time quantitative allele-specific oligonucleotide IGH polymerase chain reaction; RQ-ASO IGH PCR) approach. Results Forty-two CLL patient samples were repeatedly analyzed after allogeneic stem cell transplantation (n=20) or after fludarabine-based therapy (n=22), and 100% concordance was found using both flow cytometric protocols. Furthermore, there was a strong correlation (r=0. (en)
Title	Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. (en)
skos:prefLabel	Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. (en)
skos:notation	RIV/00216224:14740/14:00074835!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(7E13008), P(ED1.1.00/02.0068), P(EE2.3.20.0045), P(NT13493), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Loja, Tomáš Pospíšilová, Šárka Brychtová, Yvona Doubek, Michael Mayer, Jiří Krejčí, Marta Panovská, Anna Tichý, Boris Skuhrová Francová, Hana Stehlíková, Olga Borský, Marek Chovancová, Jana Burčková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	10576
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00074835
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CELL; CLL; FLUDARABINE; DIAGNOSIS; SURVIVAL; TRIAL (en)
http://linked.open.../riv/klicoveSlovo	CELL TRIAL CLL DIAGNOSIS SURVIVAL FLUDARABINE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6030CC0F909C]
http://linked.open...i/riv/nazevZdroje	International Journal of Laboratory Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	13 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia Molecular Characterization of B-cell Receptors and Their Relationship to Evolution of Gemonic Aberrations in Chronic Lymphocytic Leukemia Central european institute of technology Support of Professional Growth and International Integration of Research Teams in the Filed of Molecular Medicine
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Krejčí, Marta Loja, Tomáš Mayer, Jiří Panovská, Anna Pospíšilová, Šárka Tichý, Boris Skuhrová Francová, Hana Stehlíková, Olga Borský, Marek Chovancová, Jana Burčková, Kateřina
http://linked.open...ain/vavai/riv/wos	000332777000008
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1751-5521
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/ijlh.12149
http://localhost/t...ganizacniJednotka	14740

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