About: Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

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About: Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/25233930
Description	Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade. Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-delta(TNF-delta) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells. Here, we extend those studies by describing a novel mechanism participating in the regulation of CYP1B1 expression, which involves activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1). Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38delta-deficient and MSK1/2 double knockout mice, we show here that TNF-delta potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade. (en)
Title	Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway (en)
skos:prefLabel	Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway (en)
skos:notation	RIV/00216224:14740/14:00073973!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(EE2.3.30.0030), P(GA14-09979S), P(GAP503/11/1227), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Blažek, Dalibor Kabátková, Markéta Svobodová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	52125
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00073973
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CYP1B1; inflammation; p38 MAP kinase; MSK; metabolism of carcinogens (en)
http://linked.open.../riv/klicoveSlovo	inflammation CYP1B1 MSK metabolism of carcinogens p38 MAP kinase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[98F87E081494]
http://linked.open...i/riv/nazevZdroje	Carcinogenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of Cdk12 and C-terminal domain of RNA polymerase II in transcription-coupled genome instability Interactions of inflammatory mediators and Ah receptor signaling in toxic effects of polycyclic aromatic hydrocarbons Central european institute of technology Development of human resources in the field of cell biology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Svobodová, Jana Vondráček, Jan Kohoutek, Jiří Machala, Miroslav Blažek, Dalibor Kabátková, Markéta Šmerdová, Lenka
http://linked.open...ain/vavai/riv/wos	000345835800017
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0143-3334
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/carcin/bgu190
http://localhost/t...ganizacniJednotka	14740

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