About: Cell differentiation along multiple pathways accompanied by changes in histone acetylation status

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4
Description	Post-translational modification of histones is fundamental to the regulation of basic nuclear processes and subsequent cellular events, including differentiation. In this study, we analyzed acetylated forms of histones H2A, H2B, and H4 during induced differentiation in mouse (mESCs) and human (hESCs) embryonic stem cells and during induced enterocytic differentiation of colon cancer cells in vitro. Endoderm-like differentiation of mESCs induced by retinoic acid and enterocytic differentiation induced by histone deacetylase inhibitor sodium butyrate were accompanied by increased mono-, di-, and tri-acetylation of histone H2B and a pronounced increase in di- and tri-acetylation of histone H4. In enterocytes, mono- acetylation of histone H2A also increased and tetra-acetylation of histone H4 appeared only after induction of this differentiation pathway. During differentiation of hESCs, we observed increased mono-acetylation and decreased tri-acetylation of H2B. Post-translational modification of histones is fundamental to the regulation of basic nuclear processes and subsequent cellular events, including differentiation. In this study, we analyzed acetylated forms of histones H2A, H2B, and H4 during induced differentiation in mouse (mESCs) and human (hESCs) embryonic stem cells and during induced enterocytic differentiation of colon cancer cells in vitro. Endoderm-like differentiation of mESCs induced by retinoic acid and enterocytic differentiation induced by histone deacetylase inhibitor sodium butyrate were accompanied by increased mono-, di-, and tri-acetylation of histone H2B and a pronounced increase in di- and tri-acetylation of histone H4. In enterocytes, mono- acetylation of histone H2A also increased and tetra-acetylation of histone H4 appeared only after induction of this differentiation pathway. During differentiation of hESCs, we observed increased mono-acetylation and decreased tri-acetylation of H2B. (en)
Title	Cell differentiation along multiple pathways accompanied by changes in histone acetylation status Cell differentiation along multiple pathways accompanied by changes in histone acetylation status (en)
skos:prefLabel	Cell differentiation along multiple pathways accompanied by changes in histone acetylation status Cell differentiation along multiple pathways accompanied by changes in histone acetylation status (en)
skos:notation	RIV/00216224:14740/14:00073697!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(EE2.3.30.0009), P(GA13-07822S), P(GAP302/10/1022), P(GBP302/12/G157), P(LD11020), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zdráhal, Zbyněk Lochmanová, Gabriela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	6394
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00073697
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NEWLY SYNTHESIZED HISTONES; EMBRYONIC STEM-CELLS; NUCLEAR ARRANGEMENT; REPLICATION FORK; H3K9 ACETYLATION; CHROMATIN; TRANSCRIPTION; H4; COMPLEX; SITES (en)
http://linked.open.../riv/klicoveSlovo	CHROMATIN EMBRYONIC STEM-CELLS SITES COMPLEX H3K9 ACETYLATION H4 NEWLY SYNTHESIZED HISTONES NUCLEAR ARRANGEMENT REPLICATION FORK TRANSCRIPTION
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[8EE2CAFEAEFB]
http://linked.open...i/riv/nazevZdroje	BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology The role of epigenetic processes in DNA repair Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Chromatin dynamics during DNA repair Epigenetics normal and tumor cells. Employment of Newly Graduated Doctors of Science for Scientific Excellence
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Zdráhal, Zbyněk Legartová, Soňa Fránek, Michal Lochmanová, Gabriela Martinet, Nadine
http://linked.open...ain/vavai/riv/wos	000334029200001
issn	0829-8211
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1139/bcb-2013-0082
http://localhost/t...ganizacniJednotka	14740

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