About: Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://nar.oxfordjournals.org/content/42/5/2919.long
Description	Telomeres, nucleoprotein structures at the ends of linear eukaryotic chromosomes, are important for the maintenance of genomic stability. Telomeres were considered as typical heterochromatic regions, but in light of recent results, this view should be reconsidered. Asymmetrically located cytosines in plant telomeric DNA repeats may be substrates for a DNA methyltransferase enzyme and indeed, it was shown that these repeats are methylated. Here, we analyse the methylation of telomeric cytosines and the length of telomeres in Arabidopsis thaliana methylation mutants (met 1-3 and ddm 1-8), and in their wild-type siblings that were germinated in the presence of hypomethylation drugs. Our results show that cytosine methylation in telomeric repeats depends on the activity of MET1 and DDM1 enzymes. Telomeres, nucleoprotein structures at the ends of linear eukaryotic chromosomes, are important for the maintenance of genomic stability. Telomeres were considered as typical heterochromatic regions, but in light of recent results, this view should be reconsidered. Asymmetrically located cytosines in plant telomeric DNA repeats may be substrates for a DNA methyltransferase enzyme and indeed, it was shown that these repeats are methylated. Here, we analyse the methylation of telomeric cytosines and the length of telomeres in Arabidopsis thaliana methylation mutants (met 1-3 and ddm 1-8), and in their wild-type siblings that were germinated in the presence of hypomethylation drugs. Our results show that cytosine methylation in telomeric repeats depends on the activity of MET1 and DDM1 enzymes. (en)
Title	Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants (en)
skos:prefLabel	Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants (en)
skos:notation	RIV/00216224:14740/14:00073694!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP501/11/0596)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Majerová, Eva Fojtová, Miloslava Fajkus, Jiří Polanská, Pavla Ogrocká, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	8451
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00073694
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA METHYLATION; CYTOSINE METHYLATION; MAMMALIAN TELOMERES; EPIGENETIC INHERITANCE; CHROMOSOME ENDS; BINDING PROTEIN; NONCODING RNA; TOBACCO CELLS; GENOME; LENGTH (en)
http://linked.open.../riv/klicoveSlovo	CYTOSINE METHYLATION MAMMALIAN TELOMERES DNA METHYLATION LENGTH GENOME BINDING PROTEIN CHROMOSOME ENDS EPIGENETIC INHERITANCE NONCODING RNA TOBACCO CELLS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[179C2FD28BD9]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Epigenetic mechanisms of plant telomeres regulation
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Janeba, Zlatko Fajkus, Jiří Fojtová, Miloslava Majerová, Eva Ogrocká, Anna Polanská, Pavla
http://linked.open...ain/vavai/riv/wos	000333093600018
issn	0305-1048
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/nar/gkt1285
http://localhost/t...ganizacniJednotka	14740

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software