About: Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam     Goto   Sponge   NotDistinct   Permalink

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Description
  • This work shows that a substantial increase in the throughput of the TOF MS-based tissue imaging can be achieved by incorporating a mirror providing high-speed precision scanning of the laser beam along the sample surface. Equipped with the scanning mirror, a laboratory-built axial MALDI TOF MS instrument utilizing a 4-kHz UV laser recorded a 100 x 100 pixel MS image in 11 min using 100 laser shots per pixel. This is almost an order of magnitude faster when compared to a modern commercial instrument equipped with 1-kHz laser.
  • This work shows that a substantial increase in the throughput of the TOF MS-based tissue imaging can be achieved by incorporating a mirror providing high-speed precision scanning of the laser beam along the sample surface. Equipped with the scanning mirror, a laboratory-built axial MALDI TOF MS instrument utilizing a 4-kHz UV laser recorded a 100 x 100 pixel MS image in 11 min using 100 laser shots per pixel. This is almost an order of magnitude faster when compared to a modern commercial instrument equipped with 1-kHz laser. (en)
Title
  • Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam
  • Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam (en)
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  • Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam
  • Rapid Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging with Scanning Desorption Laser Beam (en)
skos:notation
  • RIV/00216224:14740/14:00073489!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita
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  • P(ED1.1.00/02.0068), P(EE2.3.30.0009), P(GAP206/12/0538), P(GCP206/10/J012), S
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  • 2
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  • 41361
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  • RIV/00216224:14740/14:00073489
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  • Mass spectrometry imaging; laser beam scanning; MALDI; TOF; high-throughput (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [4F2526E00C6F]
http://linked.open...i/riv/nazevZdroje
  • Anal. Chem.
http://linked.open...in/vavai/riv/obor
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  • 86
http://linked.open...iv/tvurceVysledku
  • Preisler, Jan
  • Tomalová, Iva
  • Houška, Pavel
  • Bednařík, Antonín
  • Moskovets, Eugene
  • Kuba, Pavel
  • Krásenský, Pavel
http://linked.open...ain/vavai/riv/wos
  • 000330204500004
issn
  • 0003-2700
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/ac402823n
http://localhost/t...ganizacniJednotka
  • 14740
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