About: MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

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About: MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Abstract The relative expression levels of certain microRNAs (miRNAs) correlate with known prognostic markers in chronic lymphocytic leukemia (CLL), such as leukemia-cell expression of zeta-associated protein of 70 kDa (ZAP-70), use of unmutated immunoglobulin heavy-chain variable region genes (IGHV), chromosomal abnormalities or dysfunctional p53. Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups. How these miRNAs influence cellular activation and/or BCR signaling through the post-transcriptional regulation of critical signaling molecules (e.g. Lyn, Syk, BTK, SHIP-1, SHP1) is a topic of current research. Abstract The relative expression levels of certain microRNAs (miRNAs) correlate with known prognostic markers in chronic lymphocytic leukemia (CLL), such as leukemia-cell expression of zeta-associated protein of 70 kDa (ZAP-70), use of unmutated immunoglobulin heavy-chain variable region genes (IGHV), chromosomal abnormalities or dysfunctional p53. Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups. How these miRNAs influence cellular activation and/or BCR signaling through the post-transcriptional regulation of critical signaling molecules (e.g. Lyn, Syk, BTK, SHIP-1, SHP1) is a topic of current research. (en)
Title	MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia (en)
skos:prefLabel	MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia (en)
skos:notation	RIV/00216224:14740/13:00074731!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0009), P(NT11218)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Mráz, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	88203
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00074731
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CLL; miRNA; ZAP-70; BCR-signaling; prognostic marker; immunoglobulin (en)
http://linked.open.../riv/klicoveSlovo	prognostic marker ZAP-70 CLL miRNA immunoglobulin BCR-signaling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A039C58AFDC1]
http://linked.open...i/riv/nazevZdroje	LEUKEMIA & LYMPHOMA
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Employment of Newly Graduated Doctors of Science for Scientific Excellence Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Mráz, Marek Kipps, T.
http://linked.open...ain/vavai/riv/wos	000321763800051
issn	1042-8194
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2013.796055
http://localhost/t...ganizacniJednotka	14740

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