About: Dopamine D-3 receptor as a new pharmacological target for the treatment of depression

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About: Dopamine D-3 receptor as a new pharmacological target for the treatment of depression Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the %22monoaminergic hypothesis%22 of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. More recently, the dopaminergic system has been implicated in the efficacy of some antidepressants, such as desipramine, amineptine, nomifensine. Dysfunction of dopaminergic neurotransmission within the mesolimbic system may contribute to anhedonia, loss of motivation and psychomotor retardation in severe depressive disorders. Dopamine D-3 receptor subtype is located both pre- and postsynaptically in brain areas regulating motivation and reward-related behavior and has been implicated in depression-like behaviors. A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the %22monoaminergic hypothesis%22 of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. More recently, the dopaminergic system has been implicated in the efficacy of some antidepressants, such as desipramine, amineptine, nomifensine. Dysfunction of dopaminergic neurotransmission within the mesolimbic system may contribute to anhedonia, loss of motivation and psychomotor retardation in severe depressive disorders. Dopamine D-3 receptor subtype is located both pre- and postsynaptically in brain areas regulating motivation and reward-related behavior and has been implicated in depression-like behaviors. (en)
Title	Dopamine D-3 receptor as a new pharmacological target for the treatment of depression Dopamine D-3 receptor as a new pharmacological target for the treatment of depression (en)
skos:prefLabel	Dopamine D-3 receptor as a new pharmacological target for the treatment of depression Dopamine D-3 receptor as a new pharmacological target for the treatment of depression (en)
skos:notation	RIV/00216224:14740/13:00072054!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Micale, Vincenzo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	70401
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00072054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Depression; Dopamine D-3 receptor; Brain-derived neurotrophic factor; Partial agonist; Treatment-resistant depression; Aripiprazole (en)
http://linked.open.../riv/klicoveSlovo	Brain-derived neurotrophic factor Depression Aripiprazole Dopamine D-3 receptor Partial agonist Treatment-resistant depression
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5041A41FD376]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	719
http://linked.open...iv/tvurceVysledku	Bucolo, Claudio Caraci, Filippo Drag, Filippo Leggio, Gian Marco Micale, Vincenzo Platania, Chiara Salomone, Salvatore
http://linked.open...ain/vavai/riv/wos	000327487200005
issn	0014-2999
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejphar.2013.07.022
http://localhost/t...ganizacniJednotka	14740

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