About: New perspectives of valproic acid in clinical practice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://informahealthcare.com/doi/abs/10.1517/13543784.2013.853037
Description	Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is also a potent class-selective histone deacetylase (HDAC) inhibitor at nontoxic therapeutic concentrations. New areas of application for VPA are currently opening up in clinical practice. Areas covered: The authors discuss VPA and how it may serve as an effective drug for cancer therapy. This is due to its ability to induce differentiation of a number of cancer cells in vitro and also to decrease tumor growth and metastases in animal models. The authors highlight how the utilization of VPA as an HDAC inhibitor is not limited to a single-agent therapy. Early clinical studies have also revealed promising potency of VPA in combination treatment with classic anticancer drugs. The authors do this by summarizing the published results and providing insight into the potential future developments for this field. Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is also a potent class-selective histone deacetylase (HDAC) inhibitor at nontoxic therapeutic concentrations. New areas of application for VPA are currently opening up in clinical practice. Areas covered: The authors discuss VPA and how it may serve as an effective drug for cancer therapy. This is due to its ability to induce differentiation of a number of cancer cells in vitro and also to decrease tumor growth and metastases in animal models. The authors highlight how the utilization of VPA as an HDAC inhibitor is not limited to a single-agent therapy. Early clinical studies have also revealed promising potency of VPA in combination treatment with classic anticancer drugs. The authors do this by summarizing the published results and providing insight into the potential future developments for this field. (en)
Title	New perspectives of valproic acid in clinical practice New perspectives of valproic acid in clinical practice (en)
skos:prefLabel	New perspectives of valproic acid in clinical practice New perspectives of valproic acid in clinical practice (en)
skos:notation	RIV/00216224:14740/13:00070708!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(EE2.3.20.0189)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Zdráhal, Zbyněk Fajkus, Jiří Činčárová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	91646
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00070708
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CAR; combination therapy; HDAC inhibition; radiosensitization; TRAIL/Apo2L; valproic acid (en)
http://linked.open.../riv/klicoveSlovo	HDAC inhibition TRAIL/Apo2L radiosensitization combination therapy CAR valproic acid
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2FCD547AD3A4]
http://linked.open...i/riv/nazevZdroje	Expert Opinion on Investigational Drugs
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of excellence in evolutionary cytogenomics, epigenetics and cell signalling Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Zdráhal, Zbyněk Fajkus, Jiří Činčárová, Lenka
http://linked.open...ain/vavai/riv/wos	000327258300003
issn	1354-3784
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1517/13543784.2013.853037
http://localhost/t...ganizacniJednotka	14740

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