About: Structure-function relationships during transgenic telomerase expression in Arabidopsis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Structure-function relationships during transgenic telomerase expression in Arabidopsis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/23278240
Description	Although telomerase (EC 2.7.7.49) is important for genome stability and totipotency of plant cells, the principles of its regulation are not well understood. Therefore, we studied subcellular localization and function of the full-length and truncated variants of the catalytic subunit of Arabidopsis thaliana telomerase, AtTERT, in planta. Our results show that multiple sites in AtTERT may serve as nuclear localization signals, as all the studied individual domains of the AtTERT were targeted to the nucleus and/or the nucleolus. Although the introduced genomic or cDNAAtTERT transgenes display expression at transcript and protein levels, they are not able to fully complement the lack of telomerase functions in tert -/- mutants. The failure to reconstitute telomerase function in planta suggests a more complex telomerase regulation in plant cells than would be expected based on results of similar experiments in mammalian model systems. Although telomerase (EC 2.7.7.49) is important for genome stability and totipotency of plant cells, the principles of its regulation are not well understood. Therefore, we studied subcellular localization and function of the full-length and truncated variants of the catalytic subunit of Arabidopsis thaliana telomerase, AtTERT, in planta. Our results show that multiple sites in AtTERT may serve as nuclear localization signals, as all the studied individual domains of the AtTERT were targeted to the nucleus and/or the nucleolus. Although the introduced genomic or cDNAAtTERT transgenes display expression at transcript and protein levels, they are not able to fully complement the lack of telomerase functions in tert -/- mutants. The failure to reconstitute telomerase function in planta suggests a more complex telomerase regulation in plant cells than would be expected based on results of similar experiments in mammalian model systems. (en)
Title	Structure-function relationships during transgenic telomerase expression in Arabidopsis Structure-function relationships during transgenic telomerase expression in Arabidopsis (en)
skos:prefLabel	Structure-function relationships during transgenic telomerase expression in Arabidopsis Structure-function relationships during transgenic telomerase expression in Arabidopsis (en)
skos:notation	RIV/00216224:14740/13:00070046!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(EE2.3.20.0189), P(IAA500040801), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Zachová, Dagmar Mozgová, Iva Fojtová, Miloslava Fajkus, Jiří Peška, Vratislav Sýkorová, Eva Dvořáčková, Martina Schubert, Ingo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	108430
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00070046
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA-BINDING DOMAIN; REVERSE-TRANSCRIPTASE; NUCLEOLAR LOCALIZATION; CATALYTIC SUBUNIT; PLANT TRANSFORMATION; NUCLEAR-LOCALIZATION; INSERTION SITES; IMMORTAL CELLS; FOLD DOMAIN; DNA (en)
http://linked.open.../riv/klicoveSlovo	FOLD DOMAIN IMMORTAL CELLS INSERTION SITES NUCLEAR-LOCALIZATION NUCLEOLAR LOCALIZATION PLANT TRANSFORMATION RNA-BINDING DOMAIN DNA CATALYTIC SUBUNIT REVERSE-TRANSCRIPTASE
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[D5AAFB6EBFBE]
http://linked.open...i/riv/nazevZdroje	PHYSIOLOGIA PLANTARUM
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of excellence in evolutionary cytogenomics, epigenetics and cell signalling Central european institute of technology Telomeres and telomerase: transition from molecular to structural biology approach.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	149
http://linked.open...iv/tvurceVysledku	Sýkorová, Eva Fajkus, Jiří Fojtová, Miloslava Mozgová, Iva Schubert, Ingo Peška, Vratislav Zachová, Dagmar Dvořáčková, Martina Lermontova, Inna
http://linked.open...ain/vavai/riv/wos	000323157900010
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0031-9317
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/ppl.12021
http://localhost/t...ganizacniJednotka	14740

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software