About: Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1

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About: Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remitting condition characterized by chronic inflammation of the colon. Knowledge about the molecular and cellular targets of 5-ASA is limited and a clear understanding of its activity in intestinal homeostasis and interference with neoplastic progression is lacking. We sought to identify molecular pathways interfered by 5-ASA, using CRC cell lines with different genetic background. Microarray was performed for gene expression profile of 5-ASA-treated and untreated cells (HCT116 and HT29). Filtering and analysis of data identified three oncogenic pathways interfered by 5-ASA: MAPK/ERK pathway, cell adhesion and beta-catenin/Wnt signaling. PAK1 emerged as a consensus target of 5-ASA, orchestrating these pathways. We further investigated the effect of 5-ASA on cell adhesion. 5-ASA increased cell adhesion which was measured by cell adhesion assay and transcellular-resistance measurement. Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remitting condition characterized by chronic inflammation of the colon. Knowledge about the molecular and cellular targets of 5-ASA is limited and a clear understanding of its activity in intestinal homeostasis and interference with neoplastic progression is lacking. We sought to identify molecular pathways interfered by 5-ASA, using CRC cell lines with different genetic background. Microarray was performed for gene expression profile of 5-ASA-treated and untreated cells (HCT116 and HT29). Filtering and analysis of data identified three oncogenic pathways interfered by 5-ASA: MAPK/ERK pathway, cell adhesion and beta-catenin/Wnt signaling. PAK1 emerged as a consensus target of 5-ASA, orchestrating these pathways. We further investigated the effect of 5-ASA on cell adhesion. 5-ASA increased cell adhesion which was measured by cell adhesion assay and transcellular-resistance measurement. (en)
Title	Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1 Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1 (en)
skos:prefLabel	Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1 Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1 (en)
skos:notation	RIV/00216224:14740/13:00067648!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	O
http://linked.open...avai/riv/aktivity	O
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Pospíšilová, Šárka Tichý, Boris
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	87408
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00067648
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PAK1; mesalamine; beta-catenin; E-cadherin; cell adhesion (en)
http://linked.open.../riv/klicoveSlovo	beta-catenin E-cadherin cell adhesion PAK1 mesalamine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[37ADE8E6D203]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Pospíšilová, Šárka Tichý, Boris Lang, M. Borgmann, M. Campregher, Ch. Dammann, K. Evstatiev, R. Gasche, Ch. Hundsberger, H. Khare, V. Luciani, G. Lyakhovich, A. Pflueger, M.
http://linked.open...ain/vavai/riv/wos	000314143400011
issn	0006-2952
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bcp.2012.10.026
http://localhost/t...ganizacniJednotka	14740

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