About: EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma

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About: EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Renal cell carcinoma (RCC) belongs among the most common adult kidney neoplasm. Because of the lack of early warning signals, a high percentage of patients with metastatic RCC occur. Nowadays, epithelial-mesenchymal transition (EMT) as a crucial event of the tumor progression resulting in metastasis is intensively studied. EMT is a biological process in which polarized epithelial cells undergo multiple biochemical changes altering their phenotype from epithelial to mesenchymal. This phenotype change observed during the tumor metastasis development is also accompanied on a molecular level by miRNAs deregulation. In our study, we try to identify EMT-related miRNAs that can be used in clinical practice as a predictors of metastatic risk and early relapse of the RCC. Five EMT-related miRNAs were studied on 3 different groups of RCC patients. Renal cell carcinoma (RCC) belongs among the most common adult kidney neoplasm. Because of the lack of early warning signals, a high percentage of patients with metastatic RCC occur. Nowadays, epithelial-mesenchymal transition (EMT) as a crucial event of the tumor progression resulting in metastasis is intensively studied. EMT is a biological process in which polarized epithelial cells undergo multiple biochemical changes altering their phenotype from epithelial to mesenchymal. This phenotype change observed during the tumor metastasis development is also accompanied on a molecular level by miRNAs deregulation. In our study, we try to identify EMT-related miRNAs that can be used in clinical practice as a predictors of metastatic risk and early relapse of the RCC. Five EMT-related miRNAs were studied on 3 different groups of RCC patients. (en)
Title	EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma (en)
skos:prefLabel	EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma (en)
skos:notation	RIV/00216224:14740/13:00065638!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13547)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Rédová, Martina Macháčková, Táňa Héžová, Renata Mlčochová, Hana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	72731
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065638
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	EMT; renal cell carcinoma; miRNAs; predictive biomarkers; metastases (en)
http://linked.open.../riv/klicoveSlovo	EMT miRNAs predictive biomarkers metastases renal cell carcinoma
http://linked.open...ontrolniKodProRIV	[446414D20BDD]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Study od epithelial-to-mesenchymal transition associated microRNAs and genes as potential markers for prediction of risk and early detection of metastatic disease in renal cell carcinoma patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Lakomý, Radek Svoboda, Marek Vyzula, Rostislav Fabian, Pavel Poprach, Alexandr Héžová, Renata Mlčochová, Hana Lojová, Martina Macháčková, Táňa
http://localhost/t...ganizacniJednotka	14740

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