About: Genes of the microRNA biogenesis pathway are deregulated in colorectal cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides long that regulate gene expression on post-transcriptional level. Therefore, their production and maturation have to be strictly regulated. Their biogenesis starts with the transcription, which is followed by several steps that lead to processing of primary transcripts to mature miRNAs. Each step of this pathway is sophistically regulated and any disruption of control mechanisms may leads to the cancer occurrence. The aim of this study was to analyse the expression of the crucial genes involved in the biogenesis of miRNAs in colorectal cancer (CRC). Expression of 19 selected genes (EIF2C1-4, GEMIN4, DDX20, TARBP2, DICER1, XPO5, DROSHA, DGCR8, POLR2A, DDX5, DDX17, ADAR, ADARB1, TNRC6A, LIN28A/B) has been analysed in tumour tissues of 120 clinically characterized patients with CRC and in 120 parallel healthy tissues by qRT-PCR. Using Wilcoxon test, genes with different expression between tumour tissue and healthy tissue have been identified. MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides long that regulate gene expression on post-transcriptional level. Therefore, their production and maturation have to be strictly regulated. Their biogenesis starts with the transcription, which is followed by several steps that lead to processing of primary transcripts to mature miRNAs. Each step of this pathway is sophistically regulated and any disruption of control mechanisms may leads to the cancer occurrence. The aim of this study was to analyse the expression of the crucial genes involved in the biogenesis of miRNAs in colorectal cancer (CRC). Expression of 19 selected genes (EIF2C1-4, GEMIN4, DDX20, TARBP2, DICER1, XPO5, DROSHA, DGCR8, POLR2A, DDX5, DDX17, ADAR, ADARB1, TNRC6A, LIN28A/B) has been analysed in tumour tissues of 120 clinically characterized patients with CRC and in 120 parallel healthy tissues by qRT-PCR. Using Wilcoxon test, genes with different expression between tumour tissue and healthy tissue have been identified. (en)
Title	Genes of the microRNA biogenesis pathway are deregulated in colorectal cancer Genes of the microRNA biogenesis pathway are deregulated in colorectal cancer (en)
skos:prefLabel	Genes of the microRNA biogenesis pathway are deregulated in colorectal cancer Genes of the microRNA biogenesis pathway are deregulated in colorectal cancer (en)
skos:notation	RIV/00216224:14740/13:00065633!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13549)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kovaříková, Alena Slabý, Ondřej Faltejsková, Petra
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	76366
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065633
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; miRNA biogenesis; biomarkers; therapeutic targets (en)
http://linked.open.../riv/klicoveSlovo	biomarkers colorectal cancer therapeutic targets miRNA biogenesis
http://linked.open...ontrolniKodProRIV	[13A17AD10DBA]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav Vychytilová, Petra Kovaříková, Alena
http://localhost/t...ganizacniJednotka	14740

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