About: MicroRNAs targeting EGFR signalling pathway in colorectal cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
Description	MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. (en)
Title	MicroRNAs targeting EGFR signalling pathway in colorectal cancer MicroRNAs targeting EGFR signalling pathway in colorectal cancer (en)
skos:prefLabel	MicroRNAs targeting EGFR signalling pathway in colorectal cancer MicroRNAs targeting EGFR signalling pathway in colorectal cancer (en)
skos:notation	RIV/00216224:14740/13:00065617!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NT13549), P(NT13860)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Svoboda, Marek Němeček, Radim Faltejsková, Petra Mlčochová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	88209
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers (en)
http://linked.open.../riv/klicoveSlovo	Colorectal cancer EGFR signalling pathway Predictive biomarkers Prognostic biomarkers MicroRNA
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9DAEFC9171BC]
http://linked.open...i/riv/nazevZdroje	Journal of cancer research and clinical oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients Analysis of EGFR signalling and microRNA expression profiles in prediction of response to anti-EGFR therapy in colorectal cancer patients with wild-type KRAS
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	139
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Němeček, Radim Vychytilová, Petra Mlčochová, Jitka
http://linked.open...ain/vavai/riv/wos	000324269200002
issn	0171-5216
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00432-013-1470-9
http://localhost/t...ganizacniJednotka	14740

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