About: The role of microRNAs in mitochondria in cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/23665507
Description	Reprogramming of the energy metabolism in cancer cell presents progressive field of cancer research. This feature is associated mainly with the mitochondria, which is major energy source of eukaryotic cells. These organelles are essential to the cell homeostasis maintenance, play an important role in intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases including cancer. Recently, it was described that microRNAs (miRNAs) regulate important signaling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Here we summarize current knowledge about miRNAs involved in mitochondrial functioning with focus on cellular energy metabolism, apoptosis and mitophagy. Reprogramming of the energy metabolism in cancer cell presents progressive field of cancer research. This feature is associated mainly with the mitochondria, which is major energy source of eukaryotic cells. These organelles are essential to the cell homeostasis maintenance, play an important role in intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases including cancer. Recently, it was described that microRNAs (miRNAs) regulate important signaling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Here we summarize current knowledge about miRNAs involved in mitochondrial functioning with focus on cellular energy metabolism, apoptosis and mitophagy. (en)
Title	The role of microRNAs in mitochondria in cancer The role of microRNAs in mitochondria in cancer (en)
skos:prefLabel	The role of microRNAs in mitochondria in cancer The role of microRNAs in mitochondria in cancer (en)
skos:notation	RIV/00216224:14740/13:00065603!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NT11214), P(NT13514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Šána, Jiří Bienertová-Vašků, Julie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	103342
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065603
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; mitochondria; Krebs cycle; apoptosis; mitophagy (en)
http://linked.open.../riv/klicoveSlovo	mitochondria mitophagy apoptosis microRNA Krebs cycle
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[FE58EFD16137]
http://linked.open...i/riv/nazevZdroje	Cancer Letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	336
http://linked.open...iv/tvurceVysledku	Bienertová Vašků, Julie Slabý, Ondřej Šána, Jiří
http://linked.open...ain/vavai/riv/wos	000321477800001
issn	0304-3835
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.canlet.2013.05.001
http://localhost/t...ganizacniJednotka	14740

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