About: MicroRNAs in solid cancer: from biomarkers to therapeutic targets

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection. MicroRNAs (miRNAs) are small non-coding RNAs 18–25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human solid tumors. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in cancer patients, and support diagnosis of origin among cancer of unknown primary site. MiRNAs’ occurrence has been repeatedly observed also in blood serum and plasma, and miRNAs as novel minimally invasive biomarkers have indicated reasonable sensitivity for cancer detection. (en)
Title	MicroRNAs in solid cancer: from biomarkers to therapeutic targets MicroRNAs in solid cancer: from biomarkers to therapeutic targets (en)
skos:prefLabel	MicroRNAs in solid cancer: from biomarkers to therapeutic targets MicroRNAs in solid cancer: from biomarkers to therapeutic targets (en)
skos:notation	RIV/00216224:14740/13:00065597!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13514), P(NT13549)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	88205
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065597
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNAs; solid cancers; biomarkers; therapeutic targets (en)
http://linked.open.../riv/klicoveSlovo	microRNAs solid cancers biomarkers therapeutic targets
http://linked.open...ontrolniKodProRIV	[8C5EBDEF1829]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej
http://localhost/t...ganizacniJednotka	14740

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