About: MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer

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About: MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: MicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumor suppressors. Methods: We determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoral tissues and identified 42 differentially expressed miRNAs. One of the most significantly altered miRNAs was miR-215, significantly down-regulated in tumor tissue. We chose miR-215 for further validation on an independent cohort of 125 clinically characterized CRC patients and for in vitro functional studies on DLD1, HCT116 and HT29 cell lines. Results: MiR-215 was proved to be significantly decreased in CRC tumor tissues (p<0.0001) and to be negatively correlated with clinical stage (p<0.0001) and tumor grade (p=0.04). In vitro analyses showed that ectopic expression of miR 215 decreases viability in DLD1 (p=0.05) and HCT116 (p=0,05) cells, increases apoptosis in HCT116 (p=0. Background: MicroRNAs (miRNAs) constitute a robust regulatory network with post-transcriptional regulatory efficiency for almost one half of human coding genes, including oncogenes and tumor suppressors. Methods: We determined the expression profile of 667 miRNAs in colorectal cancer (CRC) tissues and paired non-tumoral tissues and identified 42 differentially expressed miRNAs. One of the most significantly altered miRNAs was miR-215, significantly down-regulated in tumor tissue. We chose miR-215 for further validation on an independent cohort of 125 clinically characterized CRC patients and for in vitro functional studies on DLD1, HCT116 and HT29 cell lines. Results: MiR-215 was proved to be significantly decreased in CRC tumor tissues (p<0.0001) and to be negatively correlated with clinical stage (p<0.0001) and tumor grade (p=0.04). In vitro analyses showed that ectopic expression of miR 215 decreases viability in DLD1 (p=0.05) and HCT116 (p=0,05) cells, increases apoptosis in HCT116 (p=0. (en)
Title	MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer (en)
skos:prefLabel	MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer MiR-215 expression in tumor tissue and in vitro effects of its replacement in colorectal cancer (en)
skos:notation	RIV/00216224:14740/13:00065594!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13549)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Faltejsková, Petra Mlčochová, Jitka Šrůtová, Klára
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	88521
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065594
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNAs; colorectal cancer; in vitro analysis; miR-215 (en)
http://linked.open.../riv/klicoveSlovo	microRNAs colorectal cancer in vitro analysis miR-215
http://linked.open...ontrolniKodProRIV	[BEFDB68ACB39]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav Fabian, Pavel Vychytilová, Petra Mlčochová, Jitka Šrůtová, Klára
http://localhost/t...ganizacniJednotka	14740

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