About: Circulating miRNAs as new blood-based biomarkers for solid cancers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	miRNAs are short noncoding RNAs that post-transcriptionally regulate gene expression. miRNAs' ability to inhibit translation of oncogenes and tumor suppressor genes implies they have an involvement in carcinogenesis. Specific miRNA expression signatures have been identified in a variety of human cancers. More recently, occurrence of miRNAs in the blood serum and plasma of humans has been repeatedly observed. miRNA levels in serum and plasma are more stable, reproducible and consistent among individuals of the same species in comparison with other circulating nucleic acids. Circulating miRNAs have been successfully evaluated in a wide range of solid cancers as promising novel noninvasive biomarkers of early disease onset or relapse. miRNAs are short noncoding RNAs that post-transcriptionally regulate gene expression. miRNAs' ability to inhibit translation of oncogenes and tumor suppressor genes implies they have an involvement in carcinogenesis. Specific miRNA expression signatures have been identified in a variety of human cancers. More recently, occurrence of miRNAs in the blood serum and plasma of humans has been repeatedly observed. miRNA levels in serum and plasma are more stable, reproducible and consistent among individuals of the same species in comparison with other circulating nucleic acids. Circulating miRNAs have been successfully evaluated in a wide range of solid cancers as promising novel noninvasive biomarkers of early disease onset or relapse. (en)
Title	Circulating miRNAs as new blood-based biomarkers for solid cancers Circulating miRNAs as new blood-based biomarkers for solid cancers (en)
skos:prefLabel	Circulating miRNAs as new blood-based biomarkers for solid cancers Circulating miRNAs as new blood-based biomarkers for solid cancers (en)
skos:notation	RIV/00216224:14740/13:00065587!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NT13549), P(NT13860)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Rédová, Martina Šána, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	65504
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065587
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biomarkers; breast cancer; colorectal cancer; lung cancer; miRNA; plasma; prostate cancer; serum (en)
http://linked.open.../riv/klicoveSlovo	biomarkers breast cancer colorectal cancer lung cancer plasma prostate cancer miRNA serum
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[125628EB62EB]
http://linked.open...i/riv/nazevZdroje	Future Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients Analysis of EGFR signalling and microRNA expression profiles in prediction of response to anti-EGFR therapy in colorectal cancer patients with wild-type KRAS
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Šána, Jiří Lojová, Martina
http://linked.open...ain/vavai/riv/wos	000315966900013
issn	1479-6694
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.2217/FON.12.192
http://localhost/t...ganizacniJednotka	14740

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