About: MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

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About: MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class of naturally occurring, short non-coding RNAs that regulate gene expression at the post-transcriptional level. We determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays. Afterward, we validated the difference in miR-210 expression levels on the larger group of RCC patients (35 RCC versus 10 non-tumorous parenchyma samples). Functional in vitro experiments were performed on ACHN and CAKI-2 RCC cell lines transfected with miRNA-210 inhibitor. Cell viability, apoptosis, cell cycle, scratch wound migration assay, and invasion assay (xCELLigence) were performed. We have identified original ccRCC-specific miRNA signature in clinical samples (73 miRNAs were significantly downregulated and five miRNAs upregulated. Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class of naturally occurring, short non-coding RNAs that regulate gene expression at the post-transcriptional level. We determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays. Afterward, we validated the difference in miR-210 expression levels on the larger group of RCC patients (35 RCC versus 10 non-tumorous parenchyma samples). Functional in vitro experiments were performed on ACHN and CAKI-2 RCC cell lines transfected with miRNA-210 inhibitor. Cell viability, apoptosis, cell cycle, scratch wound migration assay, and invasion assay (xCELLigence) were performed. We have identified original ccRCC-specific miRNA signature in clinical samples (73 miRNAs were significantly downregulated and five miRNAs upregulated. (en)
Title	MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma (en)
skos:prefLabel	MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma (en)
skos:notation	RIV/00216224:14740/13:00065569!RIV14-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(LM2010004), P(NT13547)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Rédová, Martina Iliev, Robert Bešše, Andrej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	88520
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065569
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Renal cell carcinoma; MicroRNA; MiR-210; ACHN; CAKI-2; Proliferation; Invasiveness (en)
http://linked.open.../riv/klicoveSlovo	Invasiveness Proliferation Renal cell carcinoma ACHN CAKI-2 MiR-210 MicroRNA
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[2BC3E608D41F]
http://linked.open...i/riv/nazevZdroje	Tumor Biology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research Central european institute of technology Study od epithelial-to-mesenchymal transition associated microRNAs and genes as potential markers for prediction of risk and early detection of metastatic disease in renal cell carcinoma patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Doležel, Jan Radová, Lenka Slabý, Ondřej Lakomý, Radek Svoboda, Marek Vyzula, Rostislav Nekvindová, Jana Poprach, Alexandr Bešše, Andrej Iliev, Robert Lojová, Martina
http://linked.open...ain/vavai/riv/wos	000313875400056
issn	1010-4283
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s13277-012-0573-2
http://localhost/t...ganizacniJednotka	14740

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