About: Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders

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About: Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II). anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p < 0.0009) but not with SAS and TAS-20. Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II). anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p < 0.0009) but not with SAS and TAS-20. (en)
Title	Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders (en)
skos:prefLabel	Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders (en)
skos:notation	RIV/00216224:14740/12:00072801!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP407/12/1957), Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bob, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	126320
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00072801
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Depression; Anxiety; S100B protein; NSE; Cerebrospinal fluid (en)
http://linked.open.../riv/klicoveSlovo	Depression NSE S100B protein Cerebrospinal fluid Anxiety
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[EFB05D4A9565]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Autonomic predictors of stress response Central european institute of technology
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	529
http://linked.open...iv/tvurceVysledku	Bob, Petr Uher, Tomas
http://linked.open...ain/vavai/riv/wos	000311264000008
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0304-3940
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neulet.2012.09.003
http://localhost/t...ganizacniJednotka	14740

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