About: Potential biomarkers for early detection of acute graft-versus-host disease

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About: Potential biomarkers for early detection of acute graft-versus-host disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22927351
Description	Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use. Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use. (en)
Title	Potential biomarkers for early detection of acute graft-versus-host disease Potential biomarkers for early detection of acute graft-versus-host disease (en)
skos:prefLabel	Potential biomarkers for early detection of acute graft-versus-host disease Potential biomarkers for early detection of acute graft-versus-host disease (en)
skos:notation	RIV/00216224:14740/12:00064911!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS9683)
http://linked.open...iv/cisloPeriodika	7-8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pospíšilová, Šárka Doubek, Michael Mayer, Jiří Zdráhal, Zbyněk Verner, Jan Lochmanová, Gabriela Potěšil, David Tomancová, Alexandra Jedličková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	160335
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00064911
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; C-REACTIVE PROTEIN; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; ACUTE GVHD; SOLUBLE INTERLEUKIN-2-RECEPTOR; QUANTITATIVE PROTEOMICS; MAJOR COMPLICATIONS; PLASMA BIOMARKERS (en)
http://linked.open.../riv/klicoveSlovo	NECROSIS-FACTOR-ALPHA C-REACTIVE PROTEIN ACUTE GVHD BONE-MARROW-TRANSPLANTATION MAJOR COMPLICATIONS PLASMA BIOMARKERS QUANTITATIVE PROTEOMICS SERUM CYTOKINE LEVELS SOLUBLE INTERLEUKIN-2-RECEPTOR STEM-CELL TRANSPLANTATION
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9352C9BBBC0A]
http://linked.open...i/riv/nazevZdroje	Proteomics Clinical Applications
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Alterations of genome and proteome in leukemic patients with Graft-versus-Host disease
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Doubek, Michael Mayer, Jiří Pospíšilová, Šárka Verner, Jan Zdráhal, Zbyněk Lochmanová, Gabriela Potěšil, David Tomancová, Alexandra Jedličková, Lenka
http://linked.open...ain/vavai/riv/wos	000308093000005
issn	1862-8346
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/prca.201100104
http://localhost/t...ganizacniJednotka	14740

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