About: Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets     Goto   Sponge   NotDistinct   Permalink

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Description
  • Digestive tumours are the most frequent malignant tumours in the world and the leading cause of a cancer-related death. They are tough to treat once they have formed and many are not found until they have already spread to other parts of the body. Therefore, new biomarkers enabling early diagnosis of asymptomatic disease, accurate differentiation among particular clinical stages and individualization of therapy are sorely needed. With improved methods to explore the transcriptome, different types of non-coding RNAs have been identified. It was proved that these molecules are highly deregulated in cancer tissue and involved in important molecular and biological processes such as differentiation, proliferation, apoptosis, migration or cell cycle. Moreover, detailed analyses revealed that they could serve as new molecular markers useful for cancer classification, prognostic stratification, and drug response prediction.
  • Digestive tumours are the most frequent malignant tumours in the world and the leading cause of a cancer-related death. They are tough to treat once they have formed and many are not found until they have already spread to other parts of the body. Therefore, new biomarkers enabling early diagnosis of asymptomatic disease, accurate differentiation among particular clinical stages and individualization of therapy are sorely needed. With improved methods to explore the transcriptome, different types of non-coding RNAs have been identified. It was proved that these molecules are highly deregulated in cancer tissue and involved in important molecular and biological processes such as differentiation, proliferation, apoptosis, migration or cell cycle. Moreover, detailed analyses revealed that they could serve as new molecular markers useful for cancer classification, prognostic stratification, and drug response prediction. (en)
Title
  • Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets
  • Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets (en)
skos:prefLabel
  • Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets
  • Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets (en)
skos:notation
  • RIV/00216224:14740/12:00064867!RIV13-MZ0-14740___
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  • 154350
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  • RIV/00216224:14740/12:00064867
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  • microRNAs; non-coding RNAs; gastrointestinal tumours; prognosis; prediction; single nucleotide polymorphisms; expression profiling (en)
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  • [79559C2B79D4]
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  • Germany
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  • Neuveden
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  • Non-coding RNAs in Gastrointestinal Cancer: Novel Biomarkers and Therapeutic Targets
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  • Slabý, Ondřej
  • Faltejsková, Petra
number of pages
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  • LAP LAMBERT Academic Publishing
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  • 9783659189715
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  • 14740
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