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rdf:type
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rdfs:seeAlso
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Description
| - Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD. We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were divided into two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group.
- Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD. We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were divided into two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group. (en)
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Title
| - Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
- Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation (en)
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skos:prefLabel
| - Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
- Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation (en)
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skos:notation
| - RIV/00216224:14740/12:00062583!RIV13-MZ0-14740___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(ED1.1.00/02.0068), P(EE2.3.20.0045), P(NS9683), Z(MSM0021622430)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Mráz, Marek
- Pospíšilová, Šárka
- Brychtová, Yvona
- Doubek, Michael
- Mayer, Jiří
- Zdráhal, Zbyněk
- Krejčí, Marta
- Tichý, Boris
- Pavlová, Šárka
- Verner, Jan
- Trbušek, Martin
- Kabáthová, Jitka
- Tomancová, Alexandra
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14740/12:00062583
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - MONONUCLEAR-CELLS; ACUTE GVHD; BLOOD; MICROARRAYS; BIOMARKERS; THERAPY (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brychtová, Yvona
- Doubek, Michael
- Krejčí, Marta
- Mayer, Jiří
- Mráz, Marek
- Pospíšilová, Šárka
- Sedláček, Petr
- Verner, Jan
- Zdráhal, Zbyněk
- Tichý, Boris
- Pavlová, Šárka
- Trbušek, Martin
- Volejníková, Jana
- Kabáthová, Jitka
- Tomancová, Alexandra
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.exphem.2012.06.011
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http://localhost/t...ganizacniJednotka
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