About: Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation

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About: Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22771791
Description	Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD. We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were divided into two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group. Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD. We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were divided into two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group. (en)
Title	Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation (en)
skos:prefLabel	Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation (en)
skos:notation	RIV/00216224:14740/12:00062583!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(EE2.3.20.0045), P(NS9683), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Mráz, Marek Pospíšilová, Šárka Brychtová, Yvona Doubek, Michael Mayer, Jiří Zdráhal, Zbyněk Krejčí, Marta Tichý, Boris Pavlová, Šárka Verner, Jan Trbušek, Martin Kabáthová, Jitka Tomancová, Alexandra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	137795
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00062583
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MONONUCLEAR-CELLS; ACUTE GVHD; BLOOD; MICROARRAYS; BIOMARKERS; THERAPY (en)
http://linked.open.../riv/klicoveSlovo	BLOOD ACUTE GVHD BIOMARKERS MICROARRAYS MONONUCLEAR-CELLS THERAPY
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D14BBF3531BA]
http://linked.open...i/riv/nazevZdroje	Experimental Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	13 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Support of Professional Growth and International Integration of Research Teams in the Filed of Molecular Medicine Alterations of genome and proteome in leukemic patients with Graft-versus-Host disease
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Krejčí, Marta Mayer, Jiří Mráz, Marek Pospíšilová, Šárka Sedláček, Petr Verner, Jan Zdráhal, Zbyněk Tichý, Boris Pavlová, Šárka Trbušek, Martin Volejníková, Jana Kabáthová, Jitka Tomancová, Alexandra
http://linked.open...ain/vavai/riv/wos	000310182400004
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0301-472X
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.exphem.2012.06.011
http://localhost/t...ganizacniJednotka	14740

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