About: MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

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About: MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expression. High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expression. (en)
Title	MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas (en)
skos:prefLabel	MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas (en)
skos:notation	RIV/00216224:14740/12:00062179!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NT13514)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Šána, Jiří Bešše, Andrej
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	150381
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00062179
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNAs; biomarkers; oncology; therapeutic targets; high-grade gliomas (en)
http://linked.open.../riv/klicoveSlovo	microRNAs biomarkers high-grade gliomas oncology therapeutic targets
http://linked.open...ontrolniKodProRIV	[EAEB2E899DDB]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Šána, Jiří Křen, Leoš Lakomý, Radek Smrčka, Martin Vyzula, Rostislav Hankeová, Simona Bešše, Andrej
http://localhost/t...ganizacniJednotka	14740

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