About: Identification and functional analysis of microRNA deregulated in colorectal cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Colorectal cancer (CRC) is one of the most common types of cancers in the Czech Republic and it is the third leading cause of cancer-related death in the Western countries. The main reasons of high mortality are diagnosis at the stage of advanced disease, insufficient clinical classification and low level of therapy individualization associated with unsatisfactory therapy responses. That is the reason why several efforts have been made to find new biomarkers in CRC enabling early diagnosis of asymptomatic disease, accurate differentiation between particular clinical stages and individualization of the therapy. MicroRNAs (miRNAs) are small, non-coding, single-stranded RNAs, 18 25 nucleotides in length, that are endogenously expressed and post-transcriptionally regulate gene expression. Colorectal cancer (CRC) is one of the most common types of cancers in the Czech Republic and it is the third leading cause of cancer-related death in the Western countries. The main reasons of high mortality are diagnosis at the stage of advanced disease, insufficient clinical classification and low level of therapy individualization associated with unsatisfactory therapy responses. That is the reason why several efforts have been made to find new biomarkers in CRC enabling early diagnosis of asymptomatic disease, accurate differentiation between particular clinical stages and individualization of the therapy. MicroRNAs (miRNAs) are small, non-coding, single-stranded RNAs, 18 25 nucleotides in length, that are endogenously expressed and post-transcriptionally regulate gene expression. (en)
Title	Identification and functional analysis of microRNA deregulated in colorectal cancer Identification and functional analysis of microRNA deregulated in colorectal cancer (en)
skos:prefLabel	Identification and functional analysis of microRNA deregulated in colorectal cancer Identification and functional analysis of microRNA deregulated in colorectal cancer (en)
skos:notation	RIV/00216224:14740/12:00062178!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NT13549)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Faltejsková, Petra Mlčochová, Jitka Bešše, Andrej Šrůtová, Klára
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	140264
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00062178
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNAs; oncology; colorectal cancer; DLD-1; HCT-116 (en)
http://linked.open.../riv/klicoveSlovo	microRNAs colorectal cancer oncology DLD-1 HCT-116
http://linked.open...ontrolniKodProRIV	[F54E183A562A]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Development of diagnostic panel of circulating microRNAs for non-invasive early diagnostics and follow-up of colorectal cancer patients
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Radová, Lenka Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav Faltejsková, Petra Bešše, Andrej Mlčochová, Jitka Šrůtová, Klára
http://localhost/t...ganizacniJednotka	14740

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