About: Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus

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About: Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22209024
Description	The growth-associated protein 43 (GAP-43) is known as a marker of regenerating nerve fibers and their continuous remodeling in the adult human skin. The purpose of this pilot study was to investigate a possible role for GAP-43 in the detection of the early stages of small-fiber neuropathy in patients with type 2 diabetes mellitus (DM2) as compared with a well- established and validated parameter – intra-epidermal nerve fiber density (IENFD) of protein gene product 9.5 (PGP 9.5) immunoreactive intra-epidermal C fibers. In a group of 21 patients with DM2 within three years of diagnosis (13 men, 8 women; mean age 53.9 +- 12.8; range 30 – 74) and a group of 17 healthy volunteers (8 men, 9 women; mean age 55.8 +- 8.5; range 45 – 70 years), skin punch biopsies were taken from a distal calf and double immunostained with both PGP 9.5 and GAP-43. In healthy controls, 96.8% of 629 PGP 9.5 immunoreactive fibers were immunostained with GAP-43; the proportion of PGP 9. The growth-associated protein 43 (GAP-43) is known as a marker of regenerating nerve fibers and their continuous remodeling in the adult human skin. The purpose of this pilot study was to investigate a possible role for GAP-43 in the detection of the early stages of small-fiber neuropathy in patients with type 2 diabetes mellitus (DM2) as compared with a well- established and validated parameter – intra-epidermal nerve fiber density (IENFD) of protein gene product 9.5 (PGP 9.5) immunoreactive intra-epidermal C fibers. In a group of 21 patients with DM2 within three years of diagnosis (13 men, 8 women; mean age 53.9 +- 12.8; range 30 – 74) and a group of 17 healthy volunteers (8 men, 9 women; mean age 55.8 +- 8.5; range 45 – 70 years), skin punch biopsies were taken from a distal calf and double immunostained with both PGP 9.5 and GAP-43. In healthy controls, 96.8% of 629 PGP 9.5 immunoreactive fibers were immunostained with GAP-43; the proportion of PGP 9. (en)
Title	Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus (en)
skos:prefLabel	Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus (en)
skos:notation	RIV/00216224:14740/12:00060554!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(NS9667), S
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bednařík, Josef Němec, Martin Dubový, Petr Klusáková, Ilona Moravcová, Eva Divišová, Šárka Bělobrádková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	135880
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00060554
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Growth-associated protein 43; protein gene product 9.5; skin biopsy; type 2 diabetes mellitus; diabetic neuropathy; regeneration (en)
http://linked.open.../riv/klicoveSlovo	type 2 diabetes mellitus diabetic neuropathy Growth-associated protein 43 protein gene product 9.5 regeneration skin biopsy
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[0D9F6CD18609]
http://linked.open...i/riv/nazevZdroje	Journal of Neurological Sciences
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Painful diabetic neuropathy
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	315
http://linked.open...iv/tvurceVysledku	Bednařík, Josef Dubový, Petr Klusáková, Ilona Němec, Martin Vlčková, Eva Bělobrádková, Jana Divišová, Šárka
http://linked.open...ain/vavai/riv/wos	000302445600011
issn	0022-510X
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jns.2011.11.038
http://localhost/t...ganizacniJednotka	14740

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