About: MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

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About: MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://bloodjournal.hematologylibrary.org/content/119/9/2110
Description	MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several variable (V) subgenes coding for lambda immunoglobulin (IgL lambda). Recent studies describe the role of miR-650 in solid tumors, but its role in chronic lymphocytic leukemia (CLL) has not yet been studied. Our experiments demonstrate that miR-650 expression is regulated by coupled expression with its host gene for IgL lambda. This coupling provides a unique yet unobserved mechanism for microRNA gene regulation. We determine that higher expression of miR-650 is associated with a favorable CLL prognosis and influences the proliferation capacity of B cells. We also establish that in B cells, miR-650 targets proteins important in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4 (ING4), and early B-cell factor 3 (EBF3). MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several variable (V) subgenes coding for lambda immunoglobulin (IgL lambda). Recent studies describe the role of miR-650 in solid tumors, but its role in chronic lymphocytic leukemia (CLL) has not yet been studied. Our experiments demonstrate that miR-650 expression is regulated by coupled expression with its host gene for IgL lambda. This coupling provides a unique yet unobserved mechanism for microRNA gene regulation. We determine that higher expression of miR-650 is associated with a favorable CLL prognosis and influences the proliferation capacity of B cells. We also establish that in B cells, miR-650 targets proteins important in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4 (ING4), and early B-cell factor 3 (EBF3). (en)
Title	MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia (en)
skos:prefLabel	MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia (en)
skos:notation	RIV/00216224:14740/12:00059794!RIV13-MZ0-14740___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NS10439), P(NT11218), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Mráz, Marek Hampl, Aleš Pospíšilová, Šárka Brychtová, Yvona Doubek, Michael Mayer, Jiří Tichý, Boris Stano Kozubík, Kateřina Doležalová, Dáša Pavlová, Šárka Verner, Jan Trbušek, Martin Plevová, Karla Borský, Marek Musilová, Kateřina Mayerová, Veronika Černá, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	150387
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00059794
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CLL PATIENTS; SURVIVAL; SUBTYPES (en)
http://linked.open.../riv/klicoveSlovo	CLL PATIENTS SUBTYPES SURVIVAL
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E53F1D82D7B2]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	17 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development Central european institute of technology Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	119
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Hampl, Aleš Mayer, Jiří Mráz, Marek Pospíšilová, Šárka Verner, Jan Černá, Kateřina Tichý, Boris Doležalová, Dáša Pavlová, Šárka Trbušek, Martin Plevová, Karla Borský, Marek Staňo Kozubík, Kateřina Mayerová, Veronika Musilová, Kateřina
http://linked.open...ain/vavai/riv/wos	000300949500022
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0006-4971
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2011-11-394874
http://localhost/t...ganizacniJednotka	14740

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