About: Significant changes between the X-ray structure and NMR structure of delta subunit of RNA polymerase

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Description	RNA polymerase is an essential enzyme. RNAP from gram negative bacteria contain two additional subunits. The delta subunit is 173 aminoacids long and comes from Bacillus subtilis. The N terminal domain displays an ordered structure and the C terminal domain appears to be flexible and unstructured. The N terminal domain was solved either with NMR and Xray. The Xray structure showed completely different behaviour in the region corresponding to beta sheets present in NMR structure. In the Xray structure were found nickel ions which may have a significant effect on the folding of the protein. This is a strong proof that some of the proteins can be differently structured in the solution as in the crystalline phase. RNA polymerase is an essential enzyme. RNAP from gram negative bacteria contain two additional subunits. The delta subunit is 173 aminoacids long and comes from Bacillus subtilis. The N terminal domain displays an ordered structure and the C terminal domain appears to be flexible and unstructured. The N terminal domain was solved either with NMR and Xray. The Xray structure showed completely different behaviour in the region corresponding to beta sheets present in NMR structure. In the Xray structure were found nickel ions which may have a significant effect on the folding of the protein. This is a strong proof that some of the proteins can be differently structured in the solution as in the crystalline phase. (en) RNA polymerase is an essential enzyme. RNAP from gram negative bacteria contain two additional subunits. The delta subunit is 173 aminoacids long and comes from Bacillus subtilis. The N terminal domain displays an ordered structure and the C terminal domain appears to be flexible and unstructured. The N terminal domain was solved either with NMR and Xray. The Xray structure showed completely different behaviour in the region corresponding to beta sheets present in NMR structure. In the Xray structure were found nickel ions which may have a significant effect on the folding of the protein. This is a strong proof that some of the proteins can be differently structured in the solution as in the crystalline phase. (cs)
Title	Significant changes between the X-ray structure and NMR structure of delta subunit of RNA polymerase (en) Significant changes between the Xray structure and NMR structure of delta subunit of RNA polymerase Significant changes between the Xray structure and NMR structure of delta subunit of RNA polymerase (cs)
skos:prefLabel	Significant changes between the X-ray structure and NMR structure of delta subunit of RNA polymerase (en) Significant changes between the Xray structure and NMR structure of delta subunit of RNA polymerase Significant changes between the Xray structure and NMR structure of delta subunit of RNA polymerase (cs)
skos:notation	RIV/00216224:14740/12:00057460!RIV13-GA0-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GD301/09/H004)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Demo, Gabriel Žídek, Lukáš Wimmerová, Michaela Papoušková, Veronika
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	167827
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00057460
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	delta subunit comparism NMR Xray structure (en)
http://linked.open.../riv/klicoveSlovo	delta subunit comparism NMR Xray structure
http://linked.open...ontrolniKodProRIV	[978F2EE6AE02]
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Demo, Gabriel Papoušková, Veronika Wimmerová, Michaela Šanderová, Hana Žídek, Lukáš
http://localhost/t...ganizacniJednotka	14740

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