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  • Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain.
  • Cytosine-rich oligodeoxynucleotides (C-rich ODNs) play diverse roles in the regulation of protein expression at both transcriptional and translational levels. A repetitive C sequence can be responsible for some diseases. It is commonly known that C-rich ODNs form the stable i-motif structure, interesting due to a crucial role in the process of genetic information transfer. The aim of this contribution is to find out the relationship between the structure of homo-ODNs in buffered solutions with the same ionic strength (I = 0.18 M) but with a different number of cytosines (dCx; x = 3, 4, 5, 6, 9). Using linear sweep voltammetry (LSV) and elimination voltammetry with linear scan (EVLS), electrochemical reduction signals studied on a mercury electrode reflect the conformation changes of the C-rich ODN chain. (en)
Title
  • ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
  • ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES (en)
skos:prefLabel
  • ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES
  • ELECTROCHEMICAL STUDY OF SHORT CYTOSINE OLIGONUCLEOTIDES (en)
skos:notation
  • RIV/00216224:14740/12:00057421!RIV13-GA0-14740___
http://linked.open...avai/riv/aktivita
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  • P(ED1.1.00/02.0068), P(GD106/09/H035)
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  • 133888
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  • RIV/00216224:14740/12:00057421
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  • cytosine; oligonucleotides; cyclic voltammetry; elimination voltammetry (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [B55690131D6C]
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  • Brno
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  • Brno
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  • XII. Pracovní setkání fyzikálních chemiků a elektrochemiků
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  • Balcarová, Zdeňka
  • Trnková, Libuše
  • Pilařová, Iveta
  • Gurecký, Libor
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http://linked.open.../riv/zahajeniAkce
number of pages
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  • Mendelova zemědělská a lesnická univerzita v Brně
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  • 9788073756185
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  • 14740
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