About: Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms

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About: Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1, 2] are presented. The substitution of acetate functional group(s) by phosphonate(s) has a definite impact on the kinetic inertness of the mentioned metal complexes and, therefore, this fact should be taken for possible in vivo application as BFC’s. Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1, 2] are presented. The substitution of acetate functional group(s) by phosphonate(s) has a definite impact on the kinetic inertness of the mentioned metal complexes and, therefore, this fact should be taken for possible in vivo application as BFC’s. (en)
Title	Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms (en)
skos:prefLabel	Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms (en)
skos:notation	RIV/00216224:14740/11:00054679!RIV12-MSM-14740___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(LC06035), P(ME09065), S
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vaněk, Jakub Lubal, Přemysl Ševčík, Radek Ševčíková, Romana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	230544
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/11:00054679
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Macrocyclic Ligands; thermodynamics; kinetics; Ln(III) complexes; Cu(II) ion (en)
http://linked.open.../riv/klicoveSlovo	kinetics thermodynamics Cu(II) ion Ln(III) complexes Macrocyclic Ligands
http://linked.open...ontrolniKodProRIV	[D7F89AFC5640]
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Research of new detection systems based on sensor arrays for application in speciation analysis
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Hermann, Petr Lubal, Přemysl Vaněk, Jakub Campello, MPC Martinez, Manuel Santos, Isabel Ševčík, Radek Ševčíková, Romana
http://localhost/t...ganizacniJednotka	14740

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