About: Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy

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About: Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomedcentral.com/1471-2202/12/58
Description	Repair nerve if proximal stump is unavailable and autogenous nerve grafts are insufficient for reconstructing extensive nerve damage is difficult. Alternative methods have been developed, including lateral anastomosis based on axons’ ability to send out collateral sprouts into denervated nerve. The aim of this study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve was attached in an end-to-side fashion with ulnar nerve. Animals were allowed to survive for 2 months. The present experimental study confirms end-to-side neurorrhaphy as an alternative method for reconstructing severed peripheral nerves. CNTF promotes motor reinnervation of the MCN stump after its end-toside neurorrhaphy with ulnar nerve and improves functional recovery of the biceps brachii muscle. Repair nerve if proximal stump is unavailable and autogenous nerve grafts are insufficient for reconstructing extensive nerve damage is difficult. Alternative methods have been developed, including lateral anastomosis based on axons’ ability to send out collateral sprouts into denervated nerve. The aim of this study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve was attached in an end-to-side fashion with ulnar nerve. Animals were allowed to survive for 2 months. The present experimental study confirms end-to-side neurorrhaphy as an alternative method for reconstructing severed peripheral nerves. CNTF promotes motor reinnervation of the MCN stump after its end-toside neurorrhaphy with ulnar nerve and improves functional recovery of the biceps brachii muscle. (en)
Title	Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy (en)
skos:prefLabel	Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy (en)
skos:notation	RIV/00216224:14740/11:00053056!RIV12-MZ0-14740___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NS10496), S, Z(MSM0021620816), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	58
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	190409
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/11:00053056
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NEURON REGENERATION ACCURACY; PERIPHERAL-NERVE; BRACHIAL-PLEXUS; SCHWANN-CELLS; ULNAR NERVE; SKELETAL-MUSCLE; SCIATIC-NERVE; FACTOR CNTF; ADULT-RAT; IGF-I (en)
http://linked.open.../riv/klicoveSlovo	ADULT-RAT BRACHIAL-PLEXUS FACTOR CNTF IGF-I NEURON REGENERATION ACCURACY PERIPHERAL-NERVE SCHWANN-CELLS SCIATIC-NERVE SKELETAL-MUSCLE ULNAR NERVE
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[96B63ADD389A]
http://linked.open...i/riv/nazevZdroje	BMC Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Assessment of the success rate of end-to-side anastomosis of peripheral nerves in relation to the other neurotization techniques used in clinical practice, and the application of neurotrophins incorporated by plasmids in an experimental model
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Dubový, Petr Haninec, Pavel Klusáková, Ilona Raška, Otakar Stejskal, Lubomír Čelakovský, Pavel
http://linked.open...ain/vavai/riv/wos	000293476600001
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1471-2202
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1471-2202-12-58
http://localhost/t...ganizacniJednotka	14740

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