About: Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia

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About: Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://jco.ascopubs.org/content/29/19/2703
Description	Purpose There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group. Patients and Methods We evaluated the survival of patients with CLL and p53 defects identified at our institution by p53 yeast functional assay and complementary interphase fluorescence in situ hybridization analysis detecting del(17p) from 2003 to 2010. Results A defect of the TP53 gene was identified in 100 of 550 patients. p53 mutations were strongly associated with the deletion of 17p and the unmutated IgVH locus (both P .001). Survival assessed from the time of abnormality detection was significantly reduced in patients with both missense (P .001) and nonmissense p53 mutations (P .004). Purpose There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group. Patients and Methods We evaluated the survival of patients with CLL and p53 defects identified at our institution by p53 yeast functional assay and complementary interphase fluorescence in situ hybridization analysis detecting del(17p) from 2003 to 2010. Results A defect of the TP53 gene was identified in 100 of 550 patients. p53 mutations were strongly associated with the deletion of 17p and the unmutated IgVH locus (both P .001). Survival assessed from the time of abnormality detection was significantly reduced in patients with both missense (P .001) and nonmissense p53 mutations (P .004). (en)
Title	Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia (en)
skos:prefLabel	Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia (en)
skos:notation	RIV/00216224:14740/11:00052704!RIV12-MZ0-14740___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS10439), P(NS10448), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vranová, Vladimíra Mráz, Marek Pospíšilová, Šárka Brychtová, Yvona Kuglík, Petr Doubek, Michael Mayer, Jiří Šmardová, Jana Malčíková, Jitka Svitáková, Miluše Dobeš, Petr Trbušek, Martin Skuhrová Francová, Hana Šebejová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	212679
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/11:00052704
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CLL; TP53; DNA-binding motifs; survival (en)
http://linked.open.../riv/klicoveSlovo	survival CLL TP53 DNA-binding motifs
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7CCF1A851FB3]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	14 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Kuglík, Petr Mayer, Jiří Mráz, Marek Pospíšilová, Šárka Vranová, Vladimíra Dobeš, Petr Malčíková, Jitka Skuhrová Francová, Hana Svitáková, Miluše Trbušek, Martin Šebejová, Ludmila Šmardová, Jana
http://linked.open...ain/vavai/riv/wos	000292210500024
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0732-183X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1200/JCO.2011.34.7872
http://localhost/t...ganizacniJednotka	14740

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