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  • Uncoupling protein 1 (UCP1) dissipates energy and generates heat by catalyzing back-flux of protons into the mitochondrial matrix, probably by a fatty acid cycling mechanism. If the newly discovered UCP2 and UCP3 function similarly, they will enhance peripheral energy expenditure and are potential molecular targets for the treatment of obesity. We expressed UCP2 and UCP3 in Escherichia coli and reconstituted the detergent-extracted proteins into liposomes. Ion flux studies show that purified UCP2 and UCP3 behave identically to UCP1. They catalyze electrophoretic flux of protons and alkylsulfonates, and proton flux exhibits an obligatory requirement for fatty acids. Proton flux is inhibited by purine nucleotides but with much lower affinity than observed with UCP1. These findings are consistent with the hypothesis that UCP2 and UCP3 behave as uncoupling proteins in the cell.
  • Uncoupling protein 1 (UCP1) dissipates energy and generates heat by catalyzing back-flux of protons into the mitochondrial matrix, probably by a fatty acid cycling mechanism. If the newly discovered UCP2 and UCP3 function similarly, they will enhance peripheral energy expenditure and are potential molecular targets for the treatment of obesity. We expressed UCP2 and UCP3 in Escherichia coli and reconstituted the detergent-extracted proteins into liposomes. Ion flux studies show that purified UCP2 and UCP3 behave identically to UCP1. They catalyze electrophoretic flux of protons and alkylsulfonates, and proton flux exhibits an obligatory requirement for fatty acids. Proton flux is inhibited by purine nucleotides but with much lower affinity than observed with UCP1. These findings are consistent with the hypothesis that UCP2 and UCP3 behave as uncoupling proteins in the cell. (en)
Title
  • Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
  • Transport function and regulation of mitochondrial uncoupling proteins 2 and 3 (en)
skos:prefLabel
  • Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
  • Transport function and regulation of mitochondrial uncoupling proteins 2 and 3 (en)
skos:notation
  • RIV/00216224:14330/99:00030506!RIV10-MSM-14330___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 37
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 756550
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14330/99:00030506
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • uncoupling protein; fatty acid; mitochondria (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D86913AADEB9]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 274
http://linked.open...iv/tvurceVysledku
  • Vařecha, Miroslav
  • Ježek, P.
  • Zhang, M.
  • Garlid, K. D.
  • Jabůrek, M.
  • Gimeno, R. E.
  • Tartaglia, L. A.
  • Burn, P.
  • Dembski, M.
http://linked.open...ain/vavai/riv/wos
  • 000082469700011
issn
  • 0021-9258
number of pages
http://localhost/t...ganizacniJednotka
  • 14330
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