About: Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes

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About: Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.comp-sys-bio.org/CMSB14/accepted.html
Description	Inducible genes controlled by signalling cascades may be regulated as continuously variable or as two-state on/off switche. We describe a novel stochastic model of the interface between signal transduction and transcription initiation that accommodates both possibilities. The main challenge has been the need to reconcile the dynamics of a single copy of each gene interacting with a large population of signalling molecules. Comparison of measurements of mRNA levels in live cells with the outputs of the model allows us to test its conformance with experimental data. Our approach dissects the characteristics of the interface, an essential mechanism driving the initiation as well as the production of mRNA. The model provides a range of predictions for initiation and mRNA profiles as a function of the interface parameters, and may now be more closely aligned with further experimental observations. Inducible genes controlled by signalling cascades may be regulated as continuously variable or as two-state on/off switche. We describe a novel stochastic model of the interface between signal transduction and transcription initiation that accommodates both possibilities. The main challenge has been the need to reconcile the dynamics of a single copy of each gene interacting with a large population of signalling molecules. Comparison of measurements of mRNA levels in live cells with the outputs of the model allows us to test its conformance with experimental data. Our approach dissects the characteristics of the interface, an essential mechanism driving the initiation as well as the production of mRNA. The model provides a range of predictions for initiation and mRNA profiles as a function of the interface parameters, and may now be more closely aligned with further experimental observations. (en)
Title	Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes (en)
skos:prefLabel	Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes (en)
skos:notation	RIV/00216224:14330/14:00080020!RIV15-MSM-14330___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0256)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šafránek, David Češka, Milan
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	47554
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/14:00080020
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	systems biology; probabilistic dynamical systems; RNA transcription; piece-wise deterministic Markov process (en)
http://linked.open.../riv/klicoveSlovo	systems biology RNA transcription piece-wise deterministic Markov process probabilistic dynamical systems
http://linked.open...ontrolniKodProRIV	[569646CAC072]
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Local team and international consortium for computational modelling of a cyanobacterial cell
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Kwiatkowska, Marta Češka, Milan Šafránek, David Abate, Alessandro Mahadevan, Louis Schneider, Caroline
http://localhost/t...ganizacniJednotka	14330

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