About: Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis

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About: Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs11010-011-1182-x
Description	During some apoptotic pathways, proteins apoptosis-inducing factor (AIF) and endonuclease G (EndoG) are released from the mitochondria and they translocate into the cell nuclei, where they probably participate in chromatin degradation together with other nuclear proteins. Exact mechanism of EndoG activity in cell nucleus is still unknown. We conducted a living-cell confocal fluorescence microscopy followed by an image analysis of fluorescence resonance energy transfer (FRET) to analyze the possibility of protein interactions of EndoG with histone H2B and human DNA topoisomerase II alpha (TOPO2a). Our results show that EndoG interacts with both these proteins during apoptotic cell death. Therefore, we can conclude that EndoG and TOPO2a may actively participate in apoptotic chromatin degradation. The possible existence of a degradation complex consisting of EndoG and TOPO2a and possibly other proteins like AIF and cyclophilin A have yet to be investigated. During some apoptotic pathways, proteins apoptosis-inducing factor (AIF) and endonuclease G (EndoG) are released from the mitochondria and they translocate into the cell nuclei, where they probably participate in chromatin degradation together with other nuclear proteins. Exact mechanism of EndoG activity in cell nucleus is still unknown. We conducted a living-cell confocal fluorescence microscopy followed by an image analysis of fluorescence resonance energy transfer (FRET) to analyze the possibility of protein interactions of EndoG with histone H2B and human DNA topoisomerase II alpha (TOPO2a). Our results show that EndoG interacts with both these proteins during apoptotic cell death. Therefore, we can conclude that EndoG and TOPO2a may actively participate in apoptotic chromatin degradation. The possible existence of a degradation complex consisting of EndoG and TOPO2a and possibly other proteins like AIF and cyclophilin A have yet to be investigated. (en)
Title	Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis (en)
skos:prefLabel	Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis (en)
skos:notation	RIV/00216224:14330/12:00059138!RIV13-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), P(LC535), Z(MSM0021622419)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vařecha, Miroslav Kozubek, Michal Potěšilová, Michaela Matula, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	134282
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/12:00059138
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endonuclease G; DNA topoisomerase II alpha; histone H2B; FRET; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	endonuclease G DNA topoisomerase II alpha FRET histone H2B apoptosis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[62079F39286C]
http://linked.open...i/riv/nazevZdroje	Mol Cell Biochem
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	363
http://linked.open...iv/tvurceVysledku	Matula, Pavel Kozubek, Michal Potěšilová, Michaela Vařecha, Miroslav
http://linked.open...ain/vavai/riv/wos	000300888900030
http://linked.open...n/vavai/riv/zamer	Highly Parallel and Distributed Computing Systems
issn	0300-8177
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11010-011-1182-x
http://localhost/t...ganizacniJednotka	14330

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