About: Parameter Identification and Model Ranking of Thomas Networks

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/chapter/10.1007/978-3-642-33636-2_13
Description	We propose a new methodology for identification and analysis of discrete gene networks as defined by René Thomas, supported by a tool chain: (i) given a Thomas network with partially known kinetic parameters, we reduce the number of acceptable parametrizations to those that fit time-series measurements and reflect other known constraints by an improved technique of coloured LTL model checking performing efficiently on Thomas networks in distributed environment; (ii) we introduce classification of acceptable parametrizations to identify most optimal ones; (iii) we propose two ways of visualising parametrizations dynamics wrt time-series data. Finally, computational efficiency is evaluated and the methodology is validated on bacteriophage \lambda case study. We propose a new methodology for identification and analysis of discrete gene networks as defined by René Thomas, supported by a tool chain: (i) given a Thomas network with partially known kinetic parameters, we reduce the number of acceptable parametrizations to those that fit time-series measurements and reflect other known constraints by an improved technique of coloured LTL model checking performing efficiently on Thomas networks in distributed environment; (ii) we introduce classification of acceptable parametrizations to identify most optimal ones; (iii) we propose two ways of visualising parametrizations dynamics wrt time-series data. Finally, computational efficiency is evaluated and the methodology is validated on bacteriophage \lambda case study. (en)
Title	Parameter Identification and Model Ranking of Thomas Networks Parameter Identification and Model Ranking of Thomas Networks (en)
skos:prefLabel	Parameter Identification and Model Ranking of Thomas Networks Parameter Identification and Model Ranking of Thomas Networks (en)
skos:notation	RIV/00216224:14330/12:00057781!RIV13-GA0-14330___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP202/11/0312), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šafránek, David Streck, Adam Kolčák, Juraj
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	157779
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/12:00057781
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Thomas network; parameter identification; model checking (en)
http://linked.open.../riv/klicoveSlovo	parameter identification model checking Thomas network
http://linked.open...ontrolniKodProRIV	[7EB4236EA5AF]
http://linked.open...v/mistoKonaniAkce	London
http://linked.open...i/riv/mistoVydani	Berlin
http://linked.open...i/riv/nazevZdroje	Computational Methods in Systems Biology: 10th International Conference, CMSB 2012, London, UK, October 3-5, 2012. Proceedings
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Software Components in Embedded Systems: Development and Verification
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Šafránek, David Klarner, Hannes Kolčák, Juraj Siebert, Heike Streck, Adam
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-01-01 (xsd:date)
issn	0302-9743
number of pages	20 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-3-642-33636-2_13
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	9783642336355
http://localhost/t...ganizacniJednotka	14330

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