About: Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent findings suggest that apoptotic protein apoptosis-inducing factor (AIF) may also play an important non-apoptotic function inside mitochondria. AIF was proposed to be an important component of respiratory chain complex I that is the major producer of superoxide radical. The possible role of AIF is still controversial. Superoxide production could be used as a valuable measure of complex I function, because the majority of superoxide is produced there. Therefore, we employed superoxide-specific mitochondrial fluorescence dye for detection of superoxide production. We studied an impact of AIF knockdown on function of mitochondrial complex I by analyzing superoxide production in selected cell lines. Recent findings suggest that apoptotic protein apoptosis-inducing factor (AIF) may also play an important non-apoptotic function inside mitochondria. AIF was proposed to be an important component of respiratory chain complex I that is the major producer of superoxide radical. The possible role of AIF is still controversial. Superoxide production could be used as a valuable measure of complex I function, because the majority of superoxide is produced there. Therefore, we employed superoxide-specific mitochondrial fluorescence dye for detection of superoxide production. We studied an impact of AIF knockdown on function of mitochondrial complex I by analyzing superoxide production in selected cell lines. (en)
Title	Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I (en)
skos:prefLabel	Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I (en)
skos:notation	RIV/00216224:14330/12:00057522!RIV13-GA0-14330___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GBP302/12/G157)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vařecha, Miroslav Kozubek, Michal Procházková, Jiřina Matula, Pavel Páclová, D.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	144834
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/12:00057522
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	superoxide; fluorescence microscopy; image analysis; mitochondria; telomerase (en)
http://linked.open.../riv/klicoveSlovo	telomerase image analysis mitochondria superoxide fluorescence microscopy
http://linked.open...odStatuVydavatele	AR - Argentinská republika
http://linked.open...ontrolniKodProRIV	[9D46A46D507B]
http://linked.open...i/riv/nazevZdroje	BIOCELL
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Matula, Pavel Procházková, Jiřina Kozubek, Michal Vařecha, Miroslav Cmarko, Dušan Páclová, Daniela
issn	0327-9545
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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