About: SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement

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About: SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract
Description	Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency. Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency. (en)
Title	SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement (en)
skos:prefLabel	SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement (en)
skos:notation	RIV/00216224:14330/10:00051236!RIV12-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), P(LC06027), P(LC535), P(ME 919), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Amrichová, Jana Vařecha, Miroslav Matula, Pavel Fojtová, Miloslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	291229
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00051236
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SUV39h; histone methyltransferases; telomeres; PML bodies; LMNA gene; epigenetics; chromatin structure; nuclear radial distributions; image analysis (en)
http://linked.open.../riv/klicoveSlovo	LMNA gene nuclear radial distributions chromatin structure SUV39h image analysis epigenetics PML bodies telomeres histone methyltransferases
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B1DF20C68C85]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular Biochemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions University Research Centre - Czech Myeloma Group http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20919
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	109
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Matula, Pavel Vondráček, Jan Legartová, Soňa Vařecha, Miroslav Fojtová, Miloslava Galiová, Gabriela Amrichová, Jana Harničarová, Andrea Uhlířová, Radka
http://linked.open...ain/vavai/riv/wos	000276418900010
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molecular basis of cell and tissue regulations
issn	0730-2312
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jcb.22466
http://localhost/t...ganizacniJednotka	14330

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