About: Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Imatinib is a tyrosine kinase inhibitor nowadays used as a first line therapy for newly diagnosed chronic myeloid leukaemia (CML) patients. However, some of the patients relapse after initially good response. Therefore, reliable methods for predicting of the imatinib treatment response are sought. In our research we determine the level of phosphorylated CrkL protein, known as a substrate of Bcr-Abl, by flow cytometry. Its potential predictive value as a marker of imatinib treatment response will be assessed in the monuclear cells or CD34+ cells of peripheral blood samples of new CML patients. Imatinib is a tyrosine kinase inhibitor nowadays used as a first line therapy for newly diagnosed chronic myeloid leukaemia (CML) patients. However, some of the patients relapse after initially good response. Therefore, reliable methods for predicting of the imatinib treatment response are sought. In our research we determine the level of phosphorylated CrkL protein, known as a substrate of Bcr-Abl, by flow cytometry. Its potential predictive value as a marker of imatinib treatment response will be assessed in the monuclear cells or CD34+ cells of peripheral blood samples of new CML patients. (en)
Title	Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry (en)
skos:prefLabel	Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry (en)
skos:notation	RIV/00216224:14330/10:00045382!RIV11-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ráčil, Z. Mayer, Jiří Stejskal, Stanislav Šimara, Pavel Krontorád Koutná, Irena Peterková, Martina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	253780
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00045382
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CML; imatinib; CD34+; pCrkL; flow cytometry (en)
http://linked.open.../riv/klicoveSlovo	CML flow cytometry imatinib CD34+ pCrkL
http://linked.open...ontrolniKodProRIV	[659F7795608C]
http://linked.open...v/mistoKonaniAkce	Brno, Česká Republika
http://linked.open...i/riv/mistoVydani	Brno, Česká Republika
http://linked.open...i/riv/nazevZdroje	Advances in Molecular and Cancer Biology, 2010
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Mayer, Jiří Ráčil, Zdeněk Stejskal, Stanislav Šimara, Pavel Krontorád Koutná, Irena Peterková, Martina
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2010-11-11 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	muni PRESS
https://schema.org/isbn	978-80-210-5312-0
http://localhost/t...ganizacniJednotka	14330

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