About: A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind.

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About: A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Confocal fluorescence microscopy enables the study and observation of the different structures in the cell in the high resolution. Its role in epigenetic research is finding spatial distribution and interaction of factors that can affect gene expression without change in genetic code. Combination of specific staining of DNA sequences and nuclear proteins (ImmunoFISH) help us to describe the protein distribution in the neighbourhood of targeted genes. In our early studies we had focused on the mutual spatial relation between genetic loci with described genetic activity and nuclear proteins commonly linked with the regulation of gene activity. Unfortunately, a broad distribution of the protein signal disabled the classical co-localisation analysis and we had to find an alternative approach for image analysis. Output of the presented image analysis is helpful for the co-localisation analysis of image data with broad distribution of signal and suitable for statistical analysis. Confocal fluorescence microscopy enables the study and observation of the different structures in the cell in the high resolution. Its role in epigenetic research is finding spatial distribution and interaction of factors that can affect gene expression without change in genetic code. Combination of specific staining of DNA sequences and nuclear proteins (ImmunoFISH) help us to describe the protein distribution in the neighbourhood of targeted genes. In our early studies we had focused on the mutual spatial relation between genetic loci with described genetic activity and nuclear proteins commonly linked with the regulation of gene activity. Unfortunately, a broad distribution of the protein signal disabled the classical co-localisation analysis and we had to find an alternative approach for image analysis. Output of the presented image analysis is helpful for the co-localisation analysis of image data with broad distribution of signal and suitable for statistical analysis. (en)
Title	A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind. A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind. (en)
skos:prefLabel	A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind. A novel approach to evaluation of the spatial relationship of fluorescent signals in ImunnoFISH analysis of different kind. (en)
skos:notation	RIV/00216224:14330/10:00045380!RIV11-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Daněk, Ondřej Maška, Martin Matula, Pavel Stejskal, Stanislav Krontorád Koutná, Irena
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	244815
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00045380
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	confocal microscopy; image analysis; fluorescent in situ hybridisation; immunoflourescence; nucleus (en)
http://linked.open.../riv/klicoveSlovo	image analysis confocal microscopy nucleus fluorescent in situ hybridisation immunoflourescence
http://linked.open...ontrolniKodProRIV	[4EE4CFA868CF]
http://linked.open...v/mistoKonaniAkce	Brno, Česká Republika
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Advances in Molecular and Cancer Biology, 2010
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Daněk, Ondřej Matula, Pavel Maška, Martin Kozubek, Michal Stejskal, Stanislav Krontorád Koutná, Irena
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2010-11-11 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
number of pages	53 (xsd:int)
http://purl.org/ne...btex#hasPublisher	muni PRESS
https://schema.org/isbn	978-80-210-5312-0
http://localhost/t...ganizacniJednotka	14330

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