About: The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression

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About: The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Changes in nuclear architecture play an important role in the regulation of gene expression. The importance of epigenetic changes is observed during granulopoiesis, when changes in the nuclear architecture are considered a major factor that influences the downregulation of genes. We aimed to assess the influence of chromatin condensation on the regulation of gene expression during granulopoiesis. Based on a previously published microarray analysis, we chose loci with different levels of transcriptional activity during granulopoiesis. Fluorescent in situ hybridisation (FISH) and immunofluorescent labelling of RNA polymerase II were used to determine the relationship between the transcriptional activity of gene clusters and their localisation within areas with different levels of chromatin condensation. Although active loci were positioned outside of areas of condensed chromatin, downregulation of genes during granulopoiesis was not accompanied by a shift of the downregulated loci to condensed areas. Changes in nuclear architecture play an important role in the regulation of gene expression. The importance of epigenetic changes is observed during granulopoiesis, when changes in the nuclear architecture are considered a major factor that influences the downregulation of genes. We aimed to assess the influence of chromatin condensation on the regulation of gene expression during granulopoiesis. Based on a previously published microarray analysis, we chose loci with different levels of transcriptional activity during granulopoiesis. Fluorescent in situ hybridisation (FISH) and immunofluorescent labelling of RNA polymerase II were used to determine the relationship between the transcriptional activity of gene clusters and their localisation within areas with different levels of chromatin condensation. Although active loci were positioned outside of areas of condensed chromatin, downregulation of genes during granulopoiesis was not accompanied by a shift of the downregulated loci to condensed areas. (en)
Title	The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression (en)
skos:prefLabel	The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression (en)
skos:notation	RIV/00216224:14330/10:00044622!RIV11-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), Z(MSM0021622419), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Daněk, Ondřej Maška, Martin Matula, Pavel Ručka, Zdeněk Stejskal, Stanislav Krontorád Koutná, Irena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	285684
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/10:00044622
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Granulocytes; Immunohistochemistry; RNA polymerase II; Image analysis; Cell differentiation (en)
http://linked.open.../riv/klicoveSlovo	Image analysis Cell differentiation RNA polymerase II Granulocytes Immunohistochemistry
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CB1398EC59D1]
http://linked.open...i/riv/nazevZdroje	Epigenetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Daněk, Ondřej Matula, Pavel Maška, Martin Kozubek, Michal Stejskal, Stanislav Krontorád Koutná, Irena Ručka, Zdeněk
http://linked.open...n/vavai/riv/zamer	Highly Parallel and Distributed Computing Systems Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1559-2294
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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