About: Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells     Goto   Sponge   NotDistinct   Permalink

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  • Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. We propose a model that attributes the oncogenic functions of mutp53 to its ability to interact with intronic and intergenic non-B DNA sequences and modulate gene transcription via re-organization of chromatin.
  • Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. We propose a model that attributes the oncogenic functions of mutp53 to its ability to interact with intronic and intergenic non-B DNA sequences and modulate gene transcription via re-organization of chromatin. (en)
Title
  • Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells
  • Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells (en)
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  • Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells
  • Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells (en)
skos:notation
  • RIV/00216224:14330/09:00048867!RIV11-GA0-14330___
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  • RIV/00216224:14330/09:00048867
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  • p53; triplex; gene regulation; DNA binding (en)
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  • Brázdová, Marie
  • Lexa, Matej
  • Navrátilová, L.
  • Tichý, V.
  • Deppert, W.
  • Quante, T.
  • Tolstonog, G. V.
  • Walter, K.
  • Loscher, G.
  • Togel, L.
http://localhost/t...ganizacniJednotka
  • 14330
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