About: Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells

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About: Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chronic myelogenous leukemia (CML) is characterized by genetic abnormality, the Philadelphia chromosome carrying BCR/ABL gene. This gene generates an aberrant kinase p210 (or less frequent type p190 or p230) whose unregulated activity mainly participates in the hematopoietic stem cells malignant transformation (Barnes and Melo, 2002). To fully understand the leukemogenesis it is important to describe not only p210 kinase function, but also the roles of native ABL1 and BCR kinases in the cell. We focus on localization and dynamics of these proteins in living leukemic cells that can bring new insights into the protein function. Time-lapse microscopy of living cells is a method allowing us to study proteins in their natural environmental conditions in real time. Thanks to fluorescent proteins it is possible to examine protein localization and moreover protein dynamics or protein-protein interactions in living cells (Rustom et al., 2000). Chronic myelogenous leukemia (CML) is characterized by genetic abnormality, the Philadelphia chromosome carrying BCR/ABL gene. This gene generates an aberrant kinase p210 (or less frequent type p190 or p230) whose unregulated activity mainly participates in the hematopoietic stem cells malignant transformation (Barnes and Melo, 2002). To fully understand the leukemogenesis it is important to describe not only p210 kinase function, but also the roles of native ABL1 and BCR kinases in the cell. We focus on localization and dynamics of these proteins in living leukemic cells that can bring new insights into the protein function. Time-lapse microscopy of living cells is a method allowing us to study proteins in their natural environmental conditions in real time. Thanks to fluorescent proteins it is possible to examine protein localization and moreover protein dynamics or protein-protein interactions in living cells (Rustom et al., 2000). (en)
Title	Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells (en)
skos:prefLabel	Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells (en)
skos:notation	RIV/00216224:14330/09:00036672!RIV11-MSM-14330___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B06052), P(LC535)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vařecha, Miroslav Kozubek, Michal Potěšilová, Michaela Stejskal, Stanislav Krontorád Koutná, Irena
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	346369
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/09:00036672
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	time lapse microscopy; cell immobilization (en)
http://linked.open.../riv/klicoveSlovo	cell immobilization time lapse microscopy
http://linked.open...ontrolniKodProRIV	[086AB8BE227C]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Kozubek, Michal Potěšilová, Michaela Vařecha, Miroslav Stejskal, Stanislav Krontorád Koutná, Irena
http://localhost/t...ganizacniJednotka	14330

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