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rdf:type
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Description
| - Chronic myelogenous leukemia (CML) is characterized by genetic abnormality, the Philadelphia chromosome carrying BCR/ABL gene. This gene generates an aberrant kinase p210 (or less frequent type p190 or p230) whose unregulated activity mainly participates in the hematopoietic stem cells malignant transformation (Barnes and Melo, 2002). To fully understand the leukemogenesis it is important to describe not only p210 kinase function, but also the roles of native ABL1 and BCR kinases in the cell. We focus on localization and dynamics of these proteins in living leukemic cells that can bring new insights into the protein function. Time-lapse microscopy of living cells is a method allowing us to study proteins in their natural environmental conditions in real time. Thanks to fluorescent proteins it is possible to examine protein localization and moreover protein dynamics or protein-protein interactions in living cells (Rustom et al., 2000).
- Chronic myelogenous leukemia (CML) is characterized by genetic abnormality, the Philadelphia chromosome carrying BCR/ABL gene. This gene generates an aberrant kinase p210 (or less frequent type p190 or p230) whose unregulated activity mainly participates in the hematopoietic stem cells malignant transformation (Barnes and Melo, 2002). To fully understand the leukemogenesis it is important to describe not only p210 kinase function, but also the roles of native ABL1 and BCR kinases in the cell. We focus on localization and dynamics of these proteins in living leukemic cells that can bring new insights into the protein function. Time-lapse microscopy of living cells is a method allowing us to study proteins in their natural environmental conditions in real time. Thanks to fluorescent proteins it is possible to examine protein localization and moreover protein dynamics or protein-protein interactions in living cells (Rustom et al., 2000). (en)
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Title
| - Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells
- Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells (en)
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skos:prefLabel
| - Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells
- Time-lapse living cells microscopy of cell line K562 for study of CML-associated proteins dynamics - immobilization of suspension cultured cells (en)
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skos:notation
| - RIV/00216224:14330/09:00036672!RIV11-MSM-14330___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14330/09:00036672
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - time lapse microscopy; cell immobilization (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Kozubek, Michal
- Potěšilová, Michaela
- Vařecha, Miroslav
- Stejskal, Stanislav
- Krontorád Koutná, Irena
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http://localhost/t...ganizacniJednotka
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