About: Prediction of localization and interactions of apoptotic proteins

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins. We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the membranes of various organelles. The highest concentration of AMID was observed associated with the Golgi. We did not observe its translocation into the nucleus during apoptosis. The proposed role of AMID in apoptosis was thus not observed. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modelling of proteins with unknown 3D structure: endonuclease G, CPS-6, WAH-1, and HSP70-1. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results present new data about the structure, localization, functions and interactions of proteins AMID, AIF, endonuclease G, and other proteins. (en)
Title	Prediction of localization and interactions of apoptotic proteins Prediction of localization and interactions of apoptotic proteins (en)
skos:prefLabel	Prediction of localization and interactions of apoptotic proteins Prediction of localization and interactions of apoptotic proteins (en)
skos:notation	RIV/00216224:14330/09:00029126!RIV11-GA0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06052), P(GP204/05/P090), P(LC535), Z(MSM0021622419)
http://linked.open...iv/cisloPeriodika	59
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ulman, Vladimír Vařecha, Miroslav Kozubek, Michal Matula, Pavel Zimmermann, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	335450
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/09:00029126
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AIF; apoptosis-inducing factor; AMID; AIF-homologous mitochondrion-associated inducer of death; endonuclease G; heat shock protein; DNA topoisomerase II; CPS-6; CED-3 protease suppressor; WAH-1 (en)
http://linked.open.../riv/klicoveSlovo	apoptosis-inducing factor endonuclease G AIF-homologous mitochondrion-associated inducer of death CED-3 protease suppressor DNA topoisomerase II AIF AMID CPS-6 WAH-1 heat shock protein
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6ED968DF0BB5]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Topographic and functional characterization of telomeres in various tumor cell lines determined in situ and in vivo
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Matula, Pavel Ulman, Vladimír Kozubek, Michal Vařecha, Miroslav Zimmermann, Michal Amrichová, Jana
http://linked.open...ain/vavai/riv/wos	000268893400002
http://linked.open...n/vavai/riv/zamer	Highly Parallel and Distributed Computing Systems
issn	1021-7770
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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