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  • Complexes of antigen and antibody participate in activation of the complement system. The goal of our study was to determine whether decrease in serum immunoglobulin levels in patients with hypogammaglobulinemia leads to abnormalities in complement activation. The levels of complement activation products C4d and the C5-9 complex were determined by ELISA in 30 patients with the most frequent primary hypogammaglobulinemia - common variable immunodeficiency (CVID) and in a control group of 60 (for C4d) and 40 healthy persons (for the C5-9 complex). All patients with CVID were treated by intravenous immunoglobulin in a dose of 250 - 500 mg/kg every 3 - 4 weeks. The patients had no symptoms of acute inflammatory process at the time of blood collection. The levels of the complement activation products were correlated with the serum levels of IgG (at the time of diagnosis and at the time of blood sampling) and also with the number of acute infections during the year prior to the study.
  • Complexes of antigen and antibody participate in activation of the complement system. The goal of our study was to determine whether decrease in serum immunoglobulin levels in patients with hypogammaglobulinemia leads to abnormalities in complement activation. The levels of complement activation products C4d and the C5-9 complex were determined by ELISA in 30 patients with the most frequent primary hypogammaglobulinemia - common variable immunodeficiency (CVID) and in a control group of 60 (for C4d) and 40 healthy persons (for the C5-9 complex). All patients with CVID were treated by intravenous immunoglobulin in a dose of 250 - 500 mg/kg every 3 - 4 weeks. The patients had no symptoms of acute inflammatory process at the time of blood collection. The levels of the complement activation products were correlated with the serum levels of IgG (at the time of diagnosis and at the time of blood sampling) and also with the number of acute infections during the year prior to the study. (en)
Title
  • Complement activation products in patients with common variable immunodeficiency
  • Complement activation products in patients with common variable immunodeficiency (en)
skos:prefLabel
  • Complement activation products in patients with common variable immunodeficiency
  • Complement activation products in patients with common variable immunodeficiency (en)
skos:notation
  • RIV/00216224:14330/06:00019085!RIV10-MZ0-14330___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR7921), S
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 469372
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14330/06:00019085
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Hypogammaglobulinemia; Common variable immunodeficiency; Complement system; Complement activation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [BBC9E4CA3475]
http://linked.open...i/riv/nazevZdroje
  • Scipta Medica (Brno)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 79
http://linked.open...iv/tvurceVysledku
  • Litzman, Jiří
  • Bartoňková, Dana
  • Trávník, Jan
  • Weignerová, Zdeňka
issn
  • 1211-3395
number of pages
http://localhost/t...ganizacniJednotka
  • 14330
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