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Description
| - MULTIPLE MYELOMA (MM) is characterized by monoclonal proliferation of plasma cells and represents approximately 10% of all hematologic malignancies. The clinical course of patients with MM is highly variable. Reliable genetic indicators are therefore required for their stratification and for more adequate therapy. The metaphase cytogenetic studies in MM are hampered by a low proliferative activity of myeloma cells in vitro. Therefore, interphase fluorescent in situ hybridization (I-FISH) using specific DNA probes is the technique of choice for the determination of genomic aberrations associated with this disease. However, I-FISH on bone marrow specimens do not distinguish malignant plasma cells. In order to solve this problem, various novel techniques have been designated for selection of myeloma cells. Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM.
- MULTIPLE MYELOMA (MM) is characterized by monoclonal proliferation of plasma cells and represents approximately 10% of all hematologic malignancies. The clinical course of patients with MM is highly variable. Reliable genetic indicators are therefore required for their stratification and for more adequate therapy. The metaphase cytogenetic studies in MM are hampered by a low proliferative activity of myeloma cells in vitro. Therefore, interphase fluorescent in situ hybridization (I-FISH) using specific DNA probes is the technique of choice for the determination of genomic aberrations associated with this disease. However, I-FISH on bone marrow specimens do not distinguish malignant plasma cells. In order to solve this problem, various novel techniques have been designated for selection of myeloma cells. Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM. (en)
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Title
| - Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis
- Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis (en)
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skos:prefLabel
| - Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis
- Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis (en)
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skos:notation
| - RIV/00216224:14330/06:00018067!RIV10-MZ0-14330___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(NR8183), Z(MSM0021622415)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14330/06:00018067
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Multiple myeloma; FISH; chromosomal aberrations (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
| - Brno, ILBIT MU, Kamenice 5
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Detection of chromosomal aberrations in multiple myeloma
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Hájek, Roman
- Kuglík, Petr
- Filková, Hana
- Oltová, Alexandra
- Smejkalová, Jana
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
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https://schema.org/isbn
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http://localhost/t...ganizacniJednotka
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