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Description
| - We show that common heterochromatin antigenic protein markers [HP1alpha, -betta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in acute myeloid leukemia patients, strong methylation of H3K9 and all isoforms of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed.
- We show that common heterochromatin antigenic protein markers [HP1alpha, -betta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in acute myeloid leukemia patients, strong methylation of H3K9 and all isoforms of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed. (en)
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Title
| - Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities
- Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities (en)
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skos:prefLabel
| - Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities
- Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities (en)
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skos:notation
| - RIV/00216224:14330/05:00012357!RIV10-MZ0-14330___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA202/02/0804), P(IAA1065203), P(IBS5004010), P(KSK5052113), P(ME 565), P(NC6987), Z(AV0Z5004920)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14330/05:00012357
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - human granulocytes differentiation; chromatin condensation; heterochromatin; HP1 proteins (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Leukocyte Biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kozubek, Stanislav
- Lukášová, Emilie
- Ondřej, Vladan
- Kořístek, Zdeněk
- Falk, Martin
- Kozubek, Michal
- Grigoryev, Sergei
- Kroupová, Iva
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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