About: Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show that common heterochromatin antigenic protein markers [HP1alpha, -betta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in acute myeloid leukemia patients, strong methylation of H3K9 and all isoforms of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed. We show that common heterochromatin antigenic protein markers [HP1alpha, -betta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. In patients with an acute phase of CML and in acute myeloid leukemia patients, strong methylation of H3K9 and all isoforms of HP1 are detected. In chronic forms of CML, no strong correlations among the level of histone methylation, disease progression, and modality of treatment were observed. (en)
Title	Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities (en)
skos:prefLabel	Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities (en)
skos:notation	RIV/00216224:14330/05:00012357!RIV10-MZ0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/02/0804), P(IAA1065203), P(IBS5004010), P(KSK5052113), P(ME 565), P(NC6987), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kozubek, Michal Kozubek, Stanislav Falk, Martin Kořístek, Zdeněk Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	529765
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/05:00012357
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human granulocytes differentiation; chromatin condensation; heterochromatin; HP1 proteins (en)
http://linked.open.../riv/klicoveSlovo	chromatin condensation heterochromatin HP1 proteins human granulocytes differentiation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[18BB7F1BEF21]
http://linked.open...i/riv/nazevZdroje	Journal of Leukocyte Biology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20565 Structure, expression and interaction of the genome Epigenetic control of gene expression in malignant diseases Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Ondřej, Vladan Kořístek, Zdeněk Falk, Martin Kozubek, Michal Grigoryev, Sergei Kroupová, Iva
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0741-5400
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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