About: Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells

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About: Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The reciprocal translocation between PML and RARalpha genes associated with acute promyelocytic leukemia (APL) results in disintegration of PML bodies and expression of the fusion protein PML/RARalpha in transformed APL cells. Transcription intensity of particular genes were compared between Zn-treated (APL) and untreated (healthy) U937 PIR9 cells, stably transfected by the expression vector carrying the PML/RARalpha fusion gene under the control of Zn-inducible promoter; downregulation of many genes clustered in the locus 19p13.3 and upregulation of some of those in Xq28-Xqter were revealed by microchip analysis and RT-PCR after zinc treatment. We have examined the colocalization of these up- (Xq28-qter)-regulated (19p13.3)chromosomal loci with PML bodies in normal and PML/RARalpha microspeckles in transformed APL cells respectively, as well as the changes in chromatin structure of these loci induced in APL cells by PML/RARalpha-altered transcription. The reciprocal translocation between PML and RARalpha genes associated with acute promyelocytic leukemia (APL) results in disintegration of PML bodies and expression of the fusion protein PML/RARalpha in transformed APL cells. Transcription intensity of particular genes were compared between Zn-treated (APL) and untreated (healthy) U937 PIR9 cells, stably transfected by the expression vector carrying the PML/RARalpha fusion gene under the control of Zn-inducible promoter; downregulation of many genes clustered in the locus 19p13.3 and upregulation of some of those in Xq28-Xqter were revealed by microchip analysis and RT-PCR after zinc treatment. We have examined the colocalization of these up- (Xq28-qter)-regulated (19p13.3)chromosomal loci with PML bodies in normal and PML/RARalpha microspeckles in transformed APL cells respectively, as well as the changes in chromatin structure of these loci induced in APL cells by PML/RARalpha-altered transcription. (en)
Title	Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells (en)
skos:prefLabel	Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells (en)
skos:notation	RIV/00216224:14330/04:00009698!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/02/0804), P(IAA1065203), P(IAA5004306), P(IBS5004010), P(ME 565), P(NC6987), Z(AV0Z5004920)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Kozubek, Stanislav
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	558052
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/04:00009698
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytometry (en)
http://linked.open.../riv/klicoveSlovo	Cytometry
http://linked.open...ontrolniKodProRIV	[382F3E315613]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Biophysics of the Genome
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20565 Epigenetic control of gene expression in malignant diseases Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome Human genome structure Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Falk, Martin Kozubek, Michal Dellino, Ivan Faretta, Mario Pelicci, Giuseppe Rochi, Mariano
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2004-10-12 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
number of pages	16 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masaryk University
https://schema.org/isbn	80-210-3560-9
http://localhost/t...ganizacniJednotka	14330

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