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rdf:type
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Description
| - The reciprocal translocation between PML and RARalpha genes associated with acute promyelocytic leukemia (APL) results in disintegration of PML bodies and expression of the fusion protein PML/RARalpha in transformed APL cells. Transcription intensity of particular genes were compared between Zn-treated (APL) and untreated (healthy) U937 PIR9 cells, stably transfected by the expression vector carrying the PML/RARalpha fusion gene under the control of Zn-inducible promoter; downregulation of many genes clustered in the locus 19p13.3 and upregulation of some of those in Xq28-Xqter were revealed by microchip analysis and RT-PCR after zinc treatment. We have examined the colocalization of these up- (Xq28-qter)-regulated (19p13.3)chromosomal loci with PML bodies in normal and PML/RARalpha microspeckles in transformed APL cells respectively, as well as the changes in chromatin structure of these loci induced in APL cells by PML/RARalpha-altered transcription.
- The reciprocal translocation between PML and RARalpha genes associated with acute promyelocytic leukemia (APL) results in disintegration of PML bodies and expression of the fusion protein PML/RARalpha in transformed APL cells. Transcription intensity of particular genes were compared between Zn-treated (APL) and untreated (healthy) U937 PIR9 cells, stably transfected by the expression vector carrying the PML/RARalpha fusion gene under the control of Zn-inducible promoter; downregulation of many genes clustered in the locus 19p13.3 and upregulation of some of those in Xq28-Xqter were revealed by microchip analysis and RT-PCR after zinc treatment. We have examined the colocalization of these up- (Xq28-qter)-regulated (19p13.3)chromosomal loci with PML bodies in normal and PML/RARalpha microspeckles in transformed APL cells respectively, as well as the changes in chromatin structure of these loci induced in APL cells by PML/RARalpha-altered transcription. (en)
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Title
| - Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells
- Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells (en)
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skos:prefLabel
| - Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells
- Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells (en)
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skos:notation
| - RIV/00216224:14330/04:00009698!RIV11-AV0-14330___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA202/02/0804), P(IAA1065203), P(IAA5004306), P(IBS5004010), P(ME 565), P(NC6987), Z(AV0Z5004920)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14330/04:00009698
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Kozubek, Stanislav
- Lukášová, Emilie
- Falk, Martin
- Kozubek, Michal
- Dellino, Ivan
- Faretta, Mario
- Pelicci, Giuseppe
- Rochi, Mariano
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
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https://schema.org/isbn
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http://localhost/t...ganizacniJednotka
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