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  • The structure of chromosome territory 17 in interphase nuclei was investigated using 3D FISH and 5 DNA probes. 3D positions of the corresponding signals were determined for approximately 30-40 nuclei of Go and stimulated lymphocytes. Individual territories were then superimposed one over another in such a way that signals of the same probe were as close together as possible. The results were compared with those obtained from randomly generated points in 3D space. Optimal positioning of chromosome territories showed for the first time non-random 3D structure of interphase chromosome. It is pointed out that new mathematical methods for the investigation of the chromosome structure in interphase nuclei are needed.
  • The structure of chromosome territory 17 in interphase nuclei was investigated using 3D FISH and 5 DNA probes. 3D positions of the corresponding signals were determined for approximately 30-40 nuclei of Go and stimulated lymphocytes. Individual territories were then superimposed one over another in such a way that signals of the same probe were as close together as possible. The results were compared with those obtained from randomly generated points in 3D space. Optimal positioning of chromosome territories showed for the first time non-random 3D structure of interphase chromosome. It is pointed out that new mathematical methods for the investigation of the chromosome structure in interphase nuclei are needed. (en)
Title
  • Detailed studies of the human genome 3D structure
  • Detailed studies of the human genome 3D structure (en)
skos:prefLabel
  • Detailed studies of the human genome 3D structure
  • Detailed studies of the human genome 3D structure (en)
skos:notation
  • RIV/00216224:14330/03:00009644!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita
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  • P(IAA1065203), P(IAA5004306), P(ME 565)
http://linked.open...vai/riv/dodaniDat
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  • 603245
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14330/03:00009644
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • human genome structure (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [63937FB51663]
http://linked.open...v/mistoKonaniAkce
  • Hlohovec, Czech Republic
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  • Brno
http://linked.open...i/riv/nazevZdroje
  • Biophysics of the Genome
http://linked.open...in/vavai/riv/obor
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  • Bártová, Eva
  • Kozubek, Stanislav
  • Lukášová, Emilie
  • Kozubek, Michal
  • Katsuzumi, Okumura
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
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  • Masaryk University
https://schema.org/isbn
  • 80-210-3226-X
http://localhost/t...ganizacniJednotka
  • 14330
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