About: Topography of telomeres and structure of chromosome territories in human lymphocytes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nuclear and territorial positioning of p- and q- telomeres and centromeres of chromosomes 3, 8, 9, 13 and 19 were studied by repeated FISH, high-resolution cytometry and three-dimensional image analysis in human blood lymphocytes before and after stimulation. Telomeres were found on the opposite side of the territories as compared with the centromeres for all chromosome territories investigated. Mutual distances between telomeres of submetacentric chromosomes were very short, usually shorter than centromere-to-telomere distances, which means that the chromosome territory is non-randomly folded. Telomeres are in average much nearer to the center of the cell nucleus than centromeres; q-telomeres were found in average more centrally localized as compared with p-telomeres. Consequently, we directly showed that chromosome territories in the cell nucleus are (i) polar and (ii) partially oriented in cell nuclei. Nuclear and territorial positioning of p- and q- telomeres and centromeres of chromosomes 3, 8, 9, 13 and 19 were studied by repeated FISH, high-resolution cytometry and three-dimensional image analysis in human blood lymphocytes before and after stimulation. Telomeres were found on the opposite side of the territories as compared with the centromeres for all chromosome territories investigated. Mutual distances between telomeres of submetacentric chromosomes were very short, usually shorter than centromere-to-telomere distances, which means that the chromosome territory is non-randomly folded. Telomeres are in average much nearer to the center of the cell nucleus than centromeres; q-telomeres were found in average more centrally localized as compared with p-telomeres. Consequently, we directly showed that chromosome territories in the cell nucleus are (i) polar and (ii) partially oriented in cell nuclei. (en)
Title	Topography of telomeres and structure of chromosome territories in human lymphocytes Topography of telomeres and structure of chromosome territories in human lymphocytes (en)
skos:prefLabel	Topography of telomeres and structure of chromosome territories in human lymphocytes Topography of telomeres and structure of chromosome territories in human lymphocytes (en)
skos:notation	RIV/00216224:14330/03:00008239!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/02/0804), P(GA301/01/0186), P(IAA5004306), P(IBS5004010), P(ME 565), P(NC6987), Z(MSM 143300002)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Amrichová, Jana Kozubek, Michal Kozubek, Stanislav Lukášová, Emilie
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	631154
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/03:00008239
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nuclear architecture; telomere; centromere; chromosome territory; chromatin structure; interphase chromosome; human lymphocytes; telomere association; telomere tethering (en)
http://linked.open.../riv/klicoveSlovo	chromatin structure telomere chromosome territory interphase chromosome telomere association telomere tethering human lymphocytes centromere nuclear architecture
http://linked.open...ontrolniKodProRIV	[6B3DB077DF7E]
http://linked.open...v/mistoKonaniAkce	Hlovovec, Czech Republic
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Biophysics of the Genome
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20565 Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques Epigenetic control of gene expression in malignant diseases Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells Human genome structure Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Kozubek, Michal Amrichová, Jana
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2003-04-02 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
number of pages	11 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masaryk University
https://schema.org/isbn	80-210-3226-X
http://localhost/t...ganizacniJednotka	14330

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